別品名 |
TSA, [R-(E,E)[-7-[4-(Dimethylamino)phenyl]-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide
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別包装 |
あり
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純度 |
>=98%
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分子量 |
302.37
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CAS RN® |
58880-19-6
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化合物の概要 |
HDAC inhibitor, mammalian RNA splicing modulator.
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構造 |
C17H22N2O3
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溶媒 |
Soluble in lower alchols. Slightly soluble in chloroform, ethyl acetate, acetone and benzene.
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使用目的 |
Trichostatin A is an inhibitor of class I and II HDACs that exhibits anticancer and immunomodulatory activities. Trichostatin A induces cell cycle arrest, increases phosphorylation of JNK, downregulates activity of MCM-2, induces apoptosis, and inhibits proliferation of colon cancer cells. Trichostatin A also enhances differentiation and activity of CD4+ Foxp3+ Treg cells. Additionally, trichostatin A alters mammalian RNA splicing.Trichostatin A also alters RNA splicing.
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その他 |
[融点]150℃-151℃ [外観]Beige Powder
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参考文献 |
Liu Y, He G, Wang Y, et al. MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. Toxicol Lett. 2013 Jul 31;221(1):23-30. PMID: 23770000.Donas C, Fritz M, Manriquez V, et al. Trichostatin A promotes the generation and suppressive functions of regulatory T cells. Clin Dev Immunol. 2013;2013:679804. PMID: 23737814.Cecconi D, Donadelli M, Rinalducci S,et al. Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. Proteomics. 2007 May;7(10):1644-53. PMID: 17443844.
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メーカー |
品番 |
包装 |
LKT
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T6933
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1 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
-20℃
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