別品名 Methazolastone, Temodal, Temodar, 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5- tetrazine-8-carboxamide
別包装 あり
純度 >=98%
分子量 194.15
CAS RN® 85622-93-1
化合物の概要 Imidazotetrazine, DNA alkylator.
構造 C6H6N6O2
溶媒 Soluble in DMSO to 39mg/mL, Water to 5 mg/mL, Ethanol <1mg/mL
使用目的 Temozolomide is a second generation imidazotetrazine anticancer chemotherapeutic that is clinically approved to treat gliobastoma multiforme, anaplastic astrocytoma, and oligodendrocytoma. Temozolomide acts as an alkylating agent, attaching alkyl groups to guanine bases in DNA and interfering with DNA replication. This compound is 100% orally bioavailable and enters the cerebrospinal fluid easily and quickly.
その他 [融点]212℃ (dec)
参考文献 Nagasawa DT, Chow F, Yew A, et al. Temozolomide and other potential agents for the treatment of glioblastoma multiforme. Neurosurg Clin N Am. 2012 Apr;23(2):307-22, ix. PMID: 22440874.Wesolowski JR, Rajdev P, Mukherji SK. Temozolomide (Temodar). AJNR Am J Neuroradiol. 2010 Sep;31(8):1383-4. PMID: 2053882.Friedman HS, Kerby T, Calvert H. Temozolomide and treatment of malignant glioma. Clin Cancer Res. 2000 Jul;6(7):2585-97. PMID: 10914698.Horing E, Harter PN, Seznec J, et al. The ''go or grow'' potential of gliomas is linked to the necropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress. Acta Neuropathol. 2012 Jul;124(1):83-97. PMID: 22249620.Momiyama M, Suetsugu A, Chishima T, et al. Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice. Anticancer Res. 2013 Jan;33(1):103-106. PMID: 23267133.


メーカー 品番 包装
LKT T1849 100 MG
希望販売価格 ¥44,000


当社在庫 なし
納期目安 1週間程度
保存温度 4℃




メーカー名 LKT Laboratories, Inc.
略号 LKT