別品名 |
Taxol B
|
別包装 |
あり
|
純度 |
>=98%
|
分子量 |
831.91
|
CAS RN® |
71610-00-9
|
化合物の概要 |
Diterpene found in Taxus; potential microtubule depolymerization inhibitor.
|
構造 |
C45H53NO14
|
溶媒 |
Soluble in DMSO.
|
使用目的 |
Cephalomannine is a diterpene found in Taxus that exhibits anticancer and nephroprotective activities. Cephalomannine may display anticancer activity through binding of tubulin although current research is limited. This compound suppresses cell growth of neuroblastoma and glioblastoma cells and inhibits activity of DNA polymerase. In animal models of polycystic kidney disease, cephalomannine promotes microtubule assembly and increases survival rates.
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その他 |
[外観]White Powder
|
参考文献 |
Li Y, Qin F, Wang SM, et al. Chemical studies on Taxus canadensis. Chem Biodivers. 2013 Oct;10(10):1729-53. PMID: 24130020.Oshige M, Takenouchi M, Kato Y, et al. Taxol derivatives are selective inhibitors of DNA polymerase alpha. Bioorg Med Chem. 2004 May 15;12(10):2597-601. PMID: 15110841.Woo DD, Tabancay AP Jr, Wang CJ. Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice. Kidney Int. 1997 May;51(5):1613-8. PMID: 9150481.Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9. PMID: 21573554.
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メーカー |
品番 |
包装 |
LKT
|
T0096
|
25 MG
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
-20℃
|
|