別品名 |
Suramin Sodium, Bayer 205, Antrypol, Germanin, Moranyl, Naganol, Naphuride, 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino- (4-methyl-3,1-phenylene)-carbonylimino]]bis-1,3,5- naphthalenetrisulfonic acid hexasodium salt
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別包装 |
あり
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純度 |
>=98%
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分子量 |
1429.19
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CAS RN® |
129-46-4
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化合物の概要 |
RyR agonist, SIRT, telomerase, P2Y, GPCR inhibitor.
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構造 |
C51H34N6O23S6Na6
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溶媒 |
Soluble in water. Sparingly soluble in alcohol. Insoluble in benzene, ether or chloroform.
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使用目的 |
Suramin is an inhibitor of GPCRs; it prevents guanine nucleotide exchange. Suramin inhibits SIRT, telomerase, and P2Y receptors; it also acts as an agonist at Ryanodine (RyR) receptors. Suramin exhibits anticancer, neuromodulatory, neuroprotective, antiviral, anti-parasitic, and antimalarial activities. In glioma cells, suramin inhibits cell proliferation and spheroid growth. This compound inhibits proliferation of enterovirus EV71 by preventing viral attachment to host cells. Additionally, suramin inhibits falcipain-2 activity in Plasmodium.
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その他 |
[外観]White crystalline powder
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参考文献 |
Wang Y, Qing J, Sun Y, et al. Suramin inhibits EV71 infection. Antiviral Res. 2014 Mar;103:1-6. PMID: 24374150.Marques AF, Esser D, Rosenthal PJ, et al. Falcipain-2 inhibition by suramin and suramin analogues. Bioorg Med Chem. 2013 Jul 1;21(13):3667-73. PMID: 23680445.Sakkiah S, Arooj M, Kumar MR, et al. Identification of inhibitor binding site in human sirtuin 2 using molecular docking and dynamics simulations. PLoS One. 2013;8(1):e51429. PMID: 23382805.Erguven M, Akev N, Ozdemir A, et al. The inhibitory effect of suramin on telomerase activity and spheroid growth of C6 glioma cells. Med Sci Monit. 2008 Aug;14(8):BR165-73. PMID: 18667993.Abbracchio MP, Burnstock G, Boeynaems JM, et al. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006 Sep;58(3):281-341. PMID: 16968944.Wolner I, Kassack MU, Ullmann H, et al. Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676. Br J Pharmacol. 2005 Oct;146(4):525-33. PMID: 16056233.Beindl W, Mitterauer T, Hohenegger M, et al. Inhibition of receptor/G protein coupling by suramin analogues. Mol Pharmacol. 1996 Aug;50(2):415-23. PMID: 8700151.
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メーカー |
品番 |
包装 |
LKT
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S8169
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50 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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