別品名 |
Zagam, Spara, rel-5-Amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acid
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別包装 |
あり
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純度 |
>=98%
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分子量 |
392.4
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CAS RN® |
110871-86-8
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化合物の概要 |
Fluoroquinolone; topoisomerase IV and bacterial DNA gyrase inhibitor.
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構造 |
C19H22F2N4O3
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溶媒 |
Soluble in alcohol and chloroform. Water(0.11 g/100 ml)
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使用目的 |
Sparfloxacin is a fluoroquinolone antibiotic that is clinically used to treat respiratory infections; it displays antibacterial efficacy by inhibiting DNA gyrase and topoisomerase IV. Gold(III)-chelated sparfloxacin inhibits proliferation of lymphoma, leukemia, melanoma, and lung cancer cells, displaying anticancer activity.
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その他 |
[融点]266℃-269℃ [外観]Yellow crystalline powder
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参考文献 |
Gouvea LR, Garcia LS, Lachter DR, et al. Atypical fluoroquinolone gold(III) chelates as potential anticancer agents: relevance of DNA and protein interactions for their mechanism of action. Eur J Med Chem. 2012 Sep;55:67-73. PMID: 22835721.Harding I, Simpson I. Fluoroquinolones: is there a different mechanism of action and resistance against Streptococcus pneumoniae? J Chemother. 2000 Oct;12 Suppl 4:7-15. PMID: 11131958.Schentag JJ. Sparfloxacin: a review. Clin Ther. 2000 Apr;22(4):372-87; PMID: 10823360.
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メーカー |
品番 |
包装 |
LKT
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S6000
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500 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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