別品名 |
Methylselenocysteine, Selenium-methylselenocystine, 2-Amino-3-methylselenyl propionic acid, 3-(methylseleno)-L-alanine
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別包装 |
あり
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純度 |
>=98%
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分子量 |
182.08
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CAS RN® |
26046-90-2
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化合物の概要 |
Found in plants in Astragalus, Allium, and Brassica families.
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構造 |
C4H9NO2Se
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溶媒 |
Soluble in water (5 mg/mL).
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使用目的 |
Methylselenocysteine is found in plants in the Astragalus, Allium, and Brassica genera; it exhibits cytoprotective, chemopreventive, anti-angiogenic, antioxidative, and anti-inflammatory activities. Methylselenocysteine induces phase II enzyme activity and protects organs against chemotherapy-induced toxicity. In other models, methylselenocysteine increases expression of Nrf2, heme oxygenase 1 (HO-1), catalase, and glutathione-S-transferase, protecting against radiation-induced oxidative damage. Additionally, this compound decreases activation of NF-κB, p38 MAPK, and JNK and decreases expression of iNOS in LPS-stimulated macrophages.
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その他 |
[外観]White to off white powder
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参考文献 |
Cao S, Durrani FA, Toth K, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43. PMID: 24619073.Shin HS, Yang WJ, Choi EM. The preventive effect of Se-methylselenocysteine on γ-radiation-induced oxidative stress in rat lungs. J Trace Elem Med Biol. 2013 Apr;27(2):154-9. PMID: 23176811.Bhattacharya A. Methylselenocysteine: a promising antiangiogenic agent for overcoming drug delivery barriers in solid malignancies for therapeutic synergy with anticancer drugs. Expert Opin Drug Deliv. 2011 Jun;8(6):749-63. PMID: 21473705.Pan MH, Hong HM, Lin CL, et al. Se-methylselenocysteine inhibits lipopolysaccharide-induced NF-κB activation and iNOS induction in RAW 264.7 murine macrophages. Mol Nutr Food Res. 2011 May;55(5):723-32. PMID: 21213327.Zhang J, Wang L, Anderson LB, et al. Proteomic profiling of potential molecular targets of methyl-selenium compounds in the transgenic adenocarcinoma of mouse prostate model. Cancer Prev Res (Phila). 2010 Aug;3(8):994-1006. PMID: 20647336.
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メーカー |
品番 |
包装 |
LKT
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S1848
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250 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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法規制 |
毒・安・化管
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保存温度 |
常温
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