別品名 |
Feldene, Piroftal, Roxicam, 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
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別包装 |
あり
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純度 |
>=98%
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分子量 |
331.35
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CAS RN® |
36322-90-4
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化合物の概要 |
NSAID; COX-1/2 inhibitor.
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構造 |
C15H13N3O4S
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溶媒 |
Insoluble in water. Soluble in acetonitrile.
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使用目的 |
Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, antipyretic, neuroprotective, anticancer, and chemopreventive activities. Piroxicam inhibits COX-1 and COX-2. Cu(II) complexes of piroxicam bind GC sequences of DNA. In animal models, this compound decreases development of polyps and colorectal cancer. In cellular models of Parkinson’s disease, piroxicam inhibits MPP+-induced decreases in phosphorylated Akt and neurodegeneration.
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その他 |
[融点]198℃-200℃ [外観]Off-White Crystal Powder
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参考文献 |
Chakraborty S, Bose M, Sarkar M. Spectroscopic studies of the binding of Cu(II) complexes of oxicam NSAIDs to alternating G-C and homopolymeric G-C sequences. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Mar 25;122:690-7. PMID: 24345609.Barkin RL. Topical Nonsteroidal Anti-Inflammatory Drugs: The Importance of Drug, Delivery, and Therapeutic Outcome. Am J Ther. 2012 Feb 22. [Epub ahead of print]. PMID: 22367354.Tasaki Y, Yamamoto J, Omura T, et al. Oxicam structure in non-steroidal anti-inflammatory drugs is essential to exhibit Akt-mediated neuroprotection against 1-methyl-4-phenyl pyridinium-induced cytotoxicity. Eur J Pharmacol. 2012 Feb 15;676(1-3):57-63. PMID: 22182582.Qiu ZF, Maruyama K, Sunayama K, et al. Piroxicam-induced regression of intestinal adenomatous polyps in APC(delta474) mice. J Invest Surg. 2003 Mar-Apr;16(2):71-81. PMID: 12746190.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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