Phenylhexyl isothiocyanate  

データシート 掲載ホームページ
別品名 6-Phenylhexyl isothiocyanate, PHITC
別包装 あり
純度 >=98%
分子量 219.35
CAS RN® 133920-06-6
化合物の概要 ITC found in cruciferous vegetables; HDAC inhibitor.
構造 C13H17NS
溶媒 Soluble in oraganic solvents.
使用目的 Isothiocyanates are compounds typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer chemotherapeutic, chemopreventive, anti-angiogenic, and antibiotic properties. In vitro, phenhexyl isothiocyanate (PHITC) increases caspase 3 activity and cleavage of poly(ADP)-ribose polymerase (PARP), inducing caspase-mediated apoptosis in cellular models. This compound decreases oxidation of carcinogen NNK and increases activity of NADPH:quinone oxidoreductase and glutathione S-transferase in vitro and in vivo. PHITC inhibits histone deacetylase (HDAC) activity, IL-6 receptor production, and VEGF expression; it also induces mitochondrial membrane depolarization and apoptosis in myeloma cells. In leukemia cells, PHITC inhibits expression of cyclin and increases expression of cyclin dependent kinase (CDK) inhibitors, inducing apoptosis and inhibiting growth of xenografts of these cells in animals.
その他 [外観]Clear colorless liquid
参考文献 Lu Q, Lin X, Feng J, et al. Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways. J Hematol Oncol. 2008 Jun 9;1:6. PMID: 18577263.Lu L, Liu D, Ma X, et al. The phenylhexyl isothiocyanate induces apoptosis and inhibits leukemia cell growth in vivo. Oncol Rep. 2006 Dec;16(6):1363-7. PMID: 17089062.Morse MA, Eklind KI, Hecht SS, et al. Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res. 1991 Apr 1;51(7):1846-50. PMID: 2004368.


メーカー 品番 包装
LKT P2922 500 MG
希望販売価格 ¥80,000


当社在庫 なし
納期目安 1週間程度
保存温度 -20℃




メーカー名 LKT Laboratories, Inc.
略号 LKT