データシート 掲載ホームページ
別品名 , 4-isothiocyanatobutylbenzene
別包装 あり
純度 >=98%
分子量 191.31
CAS RN® 61499-10-3
化合物の概要 Synthetic ITC.
構造 C11H13NS
溶媒 Soluble in DMSO.
使用目的 4-Phenylbutyl isothiocyanate (ITC) is a synthetic ITC that exhibits anticancer chemotherapeutic and chemopreventive activities. In vitro, this compound induces caspase 3-dependent apoptosis. 4-Phenylbutyl isothiocyanate inhibits the development of pancreatic dysplasia and adenocarcinoma in animal models; in other animals, it decreases the number of already formed lung tumors. Like other ITCs, this compound also acts as a phase II enzyme inducer.
その他 [外観]Colorless or slightly yellowish liquid[沸点]148℃-150℃
参考文献 Son HY, Nishikawa A, Furukawa F, et al. Modifying effects of 4-phenylbutyl isothiocyanate on N-nitrosobis(2-oxopropyl)amine-induced tumorigenesis in hamsters. Cancer Lett. 2000 Nov 28;160(2):141-7. PMID: 11053643.Yu R, Mandlekar S, Harvey KJ, et al. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res. 1998 Feb 1;58(3):402-8. PMID: 9458080.Guo Z, Smith TJ, Wang E, et al. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis. 1993 Jun;14(6):1167-73. PMID: 8508504.


メーカー 品番 包装
LKT P2510 5 G
希望販売価格 ¥46,000


当社在庫 なし
納期目安 1週間程度
保存温度 -20℃




メーカー名 LKT Laboratories, Inc.
略号 LKT