Phenethyl isothiocyanate  

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別品名 Phenylethyl mustard oil, 2-Isothiocyanatoethylbenzene
別包装 あり
純度 >=98%
分子量 163.24
CAS RN® 2257-09-2
化合物の概要 ITC found in cruciferous vegetables.
構造 C9H9NS
溶媒 Insoluble in water. Soluble in ethanol, DMSO.Density: 1.094g/ml
使用目的 Phenethyl isothiocyanate (PEITC) is found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer chemotherapeutic, chemopreventive, anti-angiogenic, and antibiotic properties. In vitro, PEITC increases caspase 3 activity and cleavage of poly(ADP)-ribose polymerase (PARP), inducing caspase-mediated apoptosis in Jurkat T cells and other cellular models. PEITC increases activation of JNK1, one potential mechanism behind its regulation of phase II detoxifying enzyme gene expression. Additionally, PEITC decreases levels of Bcl-xl and increases levels of Bax, also decreasing the mitochondrial membrane potential and inducing intracellular influx of free Ca2+, resulting in cell death. This compound decreases oxidation of carcinogen NNK and increases activity of NADPH:quinone oxidoreductase and glutathione S-transferase in vitro and in vivo. In glioma cells, PEITC alters PI3K/MAPK signaling to inhibit accumulation of HIF-1α and secretion of VEGF during hypoxia.Refractive index:n20/D 1.5888(lit.)
その他 [外観]Clear Pale Yellow Liquid[沸点]139 - 140℃ (14.7 hPa). Density:1.094g/ml
参考文献 Tusskorn O, Senggunprai L, Prawan A, et al Phenethyl isothiocyanate induces calcium mobilization and mitochondrial cell death pathway in cholangiocarcinoma KKU-M214 cells. BMC Cancer. 2013 Dec 5;13(1):571. PMID: 24304591.Stan SD, Singh SV, Whitcomb DC, et al. Phenethyl Isothiocyanate Inhibits Proliferation and Induces Apoptosis in Pancreatic Cancer Cells In Vitro and in a MIAPaca2 Xenograft Animal Model. Nutr Cancer. 2013 Nov 6. [Epub ahead of print]. PMID: 24195616.Gupta B, Chiang L, Chae K, et al. Phenethyl isothiocyanate inhibits hypoxia-induced accumulation of HIF-1α and VEGF expression in human glioma cells. Food Chem. 2013 Dec 1;141(3):1841-6. PMID: 23870899.Thomson SJ, Brown KK, Pullar JM, et al. Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of Bcl-2. Cancer Res. 2006 Jul 1;66(13):6772-7. PMID: 16818653.Yu R, Mandlekar S, Harvey KJ, et al. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res. 1998 Feb 1;58(3):402-8. PMID: 9458080.Yu R, Jiao JJ, Duh JL, et al. Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1. Cancer Res. 1996 Jul 1;56(13):2954-9. PMID: 8674048.Guo Z, Smith TJ, Wang E, et al. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis. 1993 Jun;14(6):1167-73. PMID: 8508504.

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メーカー 品番 包装
LKT P2508 5 G
希望販売価格 ¥14,000

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当社在庫 なし
納期目安 1週間程度
保存温度 -20℃

 

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メーカー情報
メーカー名 LKT Laboratories, Inc.
略号 LKT
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