別品名 |
3,4-Dihydroxycinnamic acid phenethyl ester, caffeic acid phenethyl ester, CAPE, 3-(3,4-Dihydroxyphenyl)-2-propenoic acid phenylethyl ester
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別包装 |
あり
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純度 |
>=98%
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分子量 |
284.31
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CAS RN® |
104594-70-9
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化合物の概要 |
Found in propolis; 5-lipoxygenase inhibitor.
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構造 |
C17H16O4
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溶媒 |
Insoluble in water. Soluble in DMSO, or ethanol.
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使用目的 |
Phenethyl caffeate is a compound found in propolis, a mixture produced by bees. Phenethyl caffeate exhibits anti-inflammatory, anti-atherosclerotic, antioxidative, cardioprotective, anti-obesity, and anticancer chemotherapeutic activities. In vitro, phenethyl caffeate inhibits IL-1β-induced expression of IL-6, MCP-1, and ICAM-1, and suppresses phosphorylation of Akt and NF-κB. In vivo, phenethyl caffeate decreases levels of AST and lactate dehydrogenase and suppresses lipid peroxidation. Phenethyl caffeate also decreases body weight gain and fat mass in animal models fed a high fat diet, potentially by inhibiting adipogenesis. In other animal models, this compound inhibits 5-lipoxygenase and decreases blood pressure, collagen deposition, and other atherosclerotic biomarkers. In animal and cellular models of colorectal cancer, phenethyl caffeate induces apoptosis and inhibits cellular and tumor growth.
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その他 |
[外観]Light yellow powder[沸点]498.6℃
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参考文献 |
Yang JW, Jung WK, Lee CM, et al. Caffeic acid phenethyl ester inhibits the inflammatory effects of interleukin-1β in human corneal fibroblasts. Immunopharmacol Immunotoxicol. 2014 Oct;36(5):371-7. PMID: 25151996.Ilhan S, Yilmaz N, Nacar E, et al. The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats. Anadolu Kardiyol Derg. 2014 Jun 3. [Epub ahead of print]. PMID: 25036319.Chiang EP, Tsai SY, Kuo YH, et al. Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways. PLoS One. 2014 Jun 24;9(6):e99631. PMID: 24960186.Shin SH, Seo SG, Min S, et al. Caffeic acid phenethyl ester, a major component of propolis, suppresses high fat diet-induced obesity through inhibiting adipogenesis at the mitotic clonal expansion stage. J Agric Food Chem. 2014 May 14;62(19):4306-12. PMID: 24611533.Hassan NA, El-Bassossy HM, Mahmoud MF, et al. Caffeic acid phenethyl ester, a 5-lipoxygenase enzyme inhibitor, alleviates diabetic atherosclerotic manifestations: effect on vascular reactivity and stiffness. Chem Biol Interact. 2014 Apr 25;213:28-36. PMID: 24508943.
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メーカー |
品番 |
包装 |
LKT
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P2400
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500 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
-20℃
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