別品名 |
Oncodazole, R 17934, [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]- carbamic acid methyl ester
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別包装 |
あり
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純度 |
>=98%
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分子量 |
301.32
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CAS RN® |
31430-18-9
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化合物の概要 |
Microtubule polymerization inhibitor.
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構造 |
C14H11N3O3S
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溶媒 |
Soluble in DMSO. Insoluble in water.
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使用目的 |
Nocodazole is an inhibitor of microtubule polymerization that exhibits anticancer and anti-parasitic activities. Nocodazole induces depolarization of the mitochondrial membrane, caspase activation, PARP cleavage, and apoptosis in chronic lymphocytic leukemia (CLL) cells. Nocodazole also kills Alveococcus larvocysts in vivo.
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その他 |
[融点]300℃ (dec) [外観]Off-white powder
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参考文献 |
Shkoliar NA, Kukhaleva IV, Legon'kov IuA, et al. Study of the therapeutic activity of nocodazole on experimental models of larval alveococcosis. Med Parazitol (Mosk). 2013 Apr-Jun;(2):20-7. PMID: 24003517.Beswick RW, Ambrose HE, Wagner SD. Nocodazole, a microtubule de-polymerising agent, induces apoptosis of chronic lymphocytic leukaemia cells associated with changes in Bcl-2 phosphorylation and expression. Leuk Res. 2006 Apr;30(4):427-36. PMID: 16162358.Rahajeng J, Giridharan SS, Naslavsky N, Caplan S. Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors. J Biol Chem. 2010 Oct 15;285(42):31918-31922. PMID: 20801876.
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メーカー |
品番 |
包装 |
LKT
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N5409
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10 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
-20℃
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