別品名 |
Jinofloxacin, Acuatim, (+-)-9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidino)-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid
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別包装 |
あり
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純度 |
>=98%
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分子量 |
360.38
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CAS RN® |
124858-35-1
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化合物の概要 |
Fluoroquinolone; bacterial DNA gyrase inhibitor.
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構造 |
C19H21FN2O4
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溶媒 |
Soluble in DMSO.
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使用目的 |
Nadifloxacin is a fluoroquinolone antibiotic that exhibits antibacterial efficacy against both gram positive and gram negative bacteria; it inhibits DNA gyrase and is clinically used to treat acne vulgaris. Nadifloxacin inhibits Proponibacterium-stimulated PBMC production of IL-12, IFN-γ, and other cytokines. Nadifloxacin also decreases production of oxidative radicals by neutrophils.
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その他 |
[融点]245℃-247℃ [外観]Pale yellow or yellow crystalline powder
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参考文献 |
Takenaka Y, Hayashi N, Takeda M, et al. Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnes. J Dermatol. 2012 Apr;39(4):350-4. PMID: 21950544.Kuwahara K, Kitazawa T, Kitagaki H, et al. Nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes. J Dermatol Sci. 2005 Apr;38(1):47-55. PMID: 15795123.Akamatsu H, Sasaki H, Kurokawa I, et al. Effect of nadifloxacin on neutrophil functions. J Int Med Res. 1995 Jan-Feb;23(1):19-26. PMID: 7774755.
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メーカー |
品番 |
包装 |
LKT
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N0114
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25 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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