別品名 |
Monensin sodium salt, Coban, Romemsin, Rumensin, 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetra- hydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl- 2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β- methoxy-α,γ,2,8-tetramethyl-1,6-dioxaspiro[4.5]- decane-7-butyric acid sodium salt
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別包装 |
あり
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純度 |
>=98%
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分子量 |
692.86
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CAS RN® |
22373-78-0
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化合物の概要 |
Polyether ionophore, autophagy inhibitor.
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構造 |
C36H61O11 Na
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溶媒 |
Insoluble in water. Soluble in DMSO, ethanol, methanol, chloroform, other organic solvents.
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使用目的 |
Monensin is a polyether antibiotic initially produced by Streptomyces that exhibits antibactieral and anti-parasitic activities. Monensin is commercially used in cattle feed; it acts as an ionophore, transporting cations across cell membranes. Monensin inhibits autophagy, interfering with the fusion of the autophagosome and the lysosome.
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その他 |
[融点]267℃-269℃ [外観]A White or Almost White Crystalline Powder
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参考文献 |
Choi HS, Jeong EH, Lee TG, et al. Autophagy Inhibition with Monensin Enhances Cell Cycle Arrest and Apoptosis Induced by mTOR or Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cells. Tuberc Respir Dis (Seoul). 2013 Jul;75(1):9-17. PMID: 23946753.Lavine MD, Arrizabalaga G. Analysis of monensin sensitivity in Toxoplasma gondii reveals autophagy as a mechanism for drug induced death. PLoS One. 2012;7(7):e42107. PMID: 22848721.
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[注意事項] |
【安衛法】この商品は、労働安全衛生法で定める皮膚等障害化学物質等を含みます。
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メーカー |
品番 |
包装 |
LKT
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M5753
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500 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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法規制 |
劇
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保存温度 |
4℃
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