Mitomycin C  

別品名 MMC, Ametycine, Mitocin-C, Mutamycin, [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5- methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
別包装 あり
純度 >=98%
分子量 334.33
CAS RN® 50-07-7
化合物の概要 Alkaloid produced by Streptomyces, DNA cross-linker; thioredoxin reductase inhibitor.
構造 C15H18N4O5
溶媒 Soluble in water (25 oC - 0.9 mg/mL), acetone, methanol, or ethanol (1 mg/mL), DMSO (15 mg/mL).
使用目的 Mitomycin C is an alkaloid initially produced by Streptomyces that exhibits antibiotic, immunomodulatory, and anticancer chemotherapeutic activities. Mitomycin C increases heart allograft transplant survival rates by decreasing activation of CD4+ T cells and lymph nodes and increasing the number of circulating Treg cells. Mitomycin C inhibits thioredoxin reductase and induces DNA cross-linking at CpG sequences. Clinically, mitomycin C is used as a combination therapy to treat cancers; it suppresses cell growth by preventing DNA strand break repair.
その他 [融点]>360℃
[外観]Blue Violet Crystals[沸点]534℃
参考文献 Liu L, Wang F, Zheng Y, et al. Pretreatment of transfused donor splenocytes and allografts with mitomycin C attenuates acute rejection in heart transplantation in mice. Transplant Proc. 2014 May;46(4):1169-74. PMID: 24815153.Paz MM, Zhang X, Lu J, et al. A new mechanism of action for the anticancer drug mitomycin C: mechanism-based inhibition of thioredoxin reductase. Chem Res Toxicol. 2012 Jul 16;25(7):1502-11. PMID: 22694104.Kang YH, Lee KA, Kim JH, et al. Mitomycin C modulates DNA-double strand break repair genes in cervical carcinoma cells. Amino Acids. 2010 Nov;39(5):1291-8. PMID: 20352460.Tomasz M. Mitomycin C: small, fast and deadly (but very selective). Chem Biol. 1995 Sep;2(9):575-9. PMID: 9383461.


メーカー 品番 包装
LKT M3377 10 MG
希望販売価格 ¥27,000


当社在庫 なし
納期目安 1週間程度
保存温度 -20℃




メーカー名 LKT Laboratories, Inc.
略号 LKT