別品名 |
MMC, Ametycine, Mitocin-C, Mutamycin, [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5- methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
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別包装 |
あり
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純度 |
>=98%
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分子量 |
334.33
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CAS RN® |
50-07-7
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化合物の概要 |
Alkaloid produced by Streptomyces, DNA cross-linker; thioredoxin reductase inhibitor.
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構造 |
C15H18N4O5
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溶媒 |
Soluble in water (25 oC - 0.9 mg/mL), acetone, methanol, or ethanol (1 mg/mL), DMSO (15 mg/mL).
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使用目的 |
Mitomycin C is an alkaloid initially produced by Streptomyces that exhibits antibiotic, immunomodulatory, and anticancer chemotherapeutic activities. Mitomycin C increases heart allograft transplant survival rates by decreasing activation of CD4+ T cells and lymph nodes and increasing the number of circulating Treg cells. Mitomycin C inhibits thioredoxin reductase and induces DNA cross-linking at CpG sequences. Clinically, mitomycin C is used as a combination therapy to treat cancers; it suppresses cell growth by preventing DNA strand break repair.
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その他 |
[融点]>360℃ [外観]Blue Violet Crystals[沸点]534℃
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参考文献 |
Liu L, Wang F, Zheng Y, et al. Pretreatment of transfused donor splenocytes and allografts with mitomycin C attenuates acute rejection in heart transplantation in mice. Transplant Proc. 2014 May;46(4):1169-74. PMID: 24815153.Paz MM, Zhang X, Lu J, et al. A new mechanism of action for the anticancer drug mitomycin C: mechanism-based inhibition of thioredoxin reductase. Chem Res Toxicol. 2012 Jul 16;25(7):1502-11. PMID: 22694104.Kang YH, Lee KA, Kim JH, et al. Mitomycin C modulates DNA-double strand break repair genes in cervical carcinoma cells. Amino Acids. 2010 Nov;39(5):1291-8. PMID: 20352460.Tomasz M. Mitomycin C: small, fast and deadly (but very selective). Chem Biol. 1995 Sep;2(9):575-9. PMID: 9383461.
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メーカー |
品番 |
包装 |
LKT
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M3377
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1 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
-20℃
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