| 別品名 |
3',4',5,7-Tetrahydroxyflavone, Digitoflavone, Cyanidenon, 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1- benzopyran-4-one
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| 別包装 |
あり
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| 純度 |
>=95%
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| 分子量 |
286.24
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| CAS RN® |
491-70-3
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| 化合物の概要 |
Flavonoid found in various plant sources; DAT and NET potentiator, HSP90, IGF-1R, PDE inhibitor, potential α2-adrenergic antagonist.
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| 構造 |
C15H10O6
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| 溶媒 |
Soluble in methanol and alkaline solutions. Slightly soluble in water. DMSO to 57 mg/mL, Ethanol to 6mg/mL
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| 使用目的 |
Luteolin is a flavonoid found in various plant sources. Luteolin exhibits antioxidative, anti-inflammatory, neuromodulatory, anti-diabetic, antihypertensive, and anticancer chemotherapeutic activities. In vitro and in vivo, luteolin inhibits LPS-induced expression of IL-6 by inhibiting JNK phosphorylation and decreasing the binding of AP-1 transcription factor to the IL-6 promoter. In animal models of experimental autoimmune encephalitis (EAE), luteolin inhibits mast cell activity and mast cell-dependent T cell activation, lessening disease pathology. Luteolin inhibits phosphodiesterases (PDE 1-5) and may also inhibit α2-adrenergic receptors as it reverses xylazine/ketamine-induced anesthesia in vivo. Luteolin also increases monoamine transport, potentially through potentiation of DAT and NET. In diabetic mice, luteolin decreases mast cell and macrophage infiltration, expression of inflammatory cytokines, glucose tolerance, insulin sensitivity, and apoptosis. Luteolin decreases systolic blood pressure in spontaneously hypertensive rats and decreases expression of MMP9 and VEGF, suppressing tumor growth in animal models with gastric cancer xenografts. Additionally, luteolin inhibits heat shock protein 90 (HSP90) and IGF-1R.
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| その他 |
[融点]~330℃ (lit.)
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| 参考文献 |
Xu N, Zhang L, Dong J, et al. Low-dose diet supplement of a natural flavonoid, luteolin, ameliorates diet-induced obesity and insulin resistance in mice. Mol Nutr Food Res. 2014 Jun;58(6):1258-68. PMID: 24668788.Chen D, Bi A, Dong X, et al. Luteolin exhibits anti-inflammatory effects by blocking the activity of heat shock protein 90 in macrophages. Biochem Biophys Res Commun. 2014 Jan 3;443(1):326-32. PMID: 24321097.Lv GY, Zhang YP, Gao JL, et al. Combined antihypertensive effect of luteolin and buddleoside enriched extracts in spontaneously hypertensive rats. J Ethnopharmacol. 2013 Nov 25;150(2):507-13. PMID: 24080032.Yang Y, Shen J, Yu X, et al. Identification of an inhibitory mechanism of luteolin on the insulin-like growth factor-1 ligand-receptor interaction. Chembiochem. 2013 May 27;14(8):929-33. PMID: 23630137.Lu XY, Li YH, Xiao XW, et al. Inhibitory effects of luteolin on human gastric carcinoma xenografts in nude mice and its mechanism. Zhonghua Yi Xue Za Zhi. 2013 Jan 8;93(2):142-6. PMID: 23648354.Yu MC, Chen JH, Lai CY, et al. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. Eur J Pharmacol. 2010 Feb 10;627(1-3):269-75. PMID: 19853596.Zhao G, Qin GW, Wang J, et al. Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt. Neurochem Int. 2010 Jan;56(1):168-76. PMID: 19815045.Theoharides TC. Luteolin as a therapeutic option for multiple sclerosis. J Neuroinflammation. 2009 Oct 13;6:29. PMID: 19825165.Jang S, Kelley KW, Johnson RW. Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. Proc Natl Acad Sci U S A. 2008 May 27;105(21):7534-9. PMID: 18490655.Kang KP, Park SK, Kim DH, et al. Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. Nephrol Dial Transplant. 2011 Mar;26(3):814-822. PMID: 20817674.
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| メーカー |
品番 |
包装 |
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LKT
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L8377
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100 MG
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※表示価格について
| 当社在庫 |
なし
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| 納期目安 |
1週間程度
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| 保存温度 |
４℃
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