別品名 |
Fungarest, Fungoral, Ketoderm., cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
|
別包装 |
あり
|
純度 |
>=98%
|
分子量 |
531.44
|
CAS RN® |
65277-42-1
|
化合物の概要 |
Imidazole; 14-α demethylase inhibitor.
|
構造 |
C26H28Cl2N4O4
|
溶媒 |
Soluble in DMSO (3 mg/mL), ethanol (7 mg/mL).
|
使用目的 |
Ketoconazole is a synthetic imidazole antifungal that also exhibits anti-androgen, anti-inflammatory, neuromodulatory, and anticancer chemotherapeutic activities. Ketoconazole is clinically used to treat fungal infections; it inhibits 14-α demethylase, preventing ergosterol production and cell wall synthesis. In clinical models of prostate cancer, ketoconazole decreases testosterone and cortisol production and inhibits androgen receptors, displaying potential chemotherapeutic benefit. In cellular models, ketoconazole activates Nrf2 and decreases production of IL-8 and TNF-α.
|
その他 |
[融点]148℃-149℃ [外観]White Powder
|
参考文献 |
Tsuji G, Takahara M, Uchi H, et al. Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: the basis of its anti-inflammatory effect. J Invest Dermatol. 2012 Jan;132(1):59-68. PMID: 21753779.Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24(8):367-70. PMID: 1526623.Witjes FJ, Debruyne FM, Fernandez del Moral P, et al. Ketoconazole high dose in management of hormonally pretreated patients with progressive metastatic prostate cancer. Dutch South-Eastern Urological Cooperative Group. Urology. 1989 May;33(5):411-5. PMID: 2652864.Loose DS, Kan PB, Hirst MA, et al. Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest. 1983 May;71(5):1495-9. PMID: 6304148.Matsumoto Y, Miyazaki S, Fukunaga DH, et al. Quantitative evaluation of cryptococcal pathogenesis and antifungal drugs using a silkworm infection model with Cryptococcus neoformans. J Appl Microbiol. 2012 Jan;112(1):138-146. PMID: 22040451.
|
※サムネイル画像をクリックすると拡大画像が表示されます。
|
|
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
常温
|
|