別品名 |
3-Methylquercetin, Quercetin- 3'-methyl ether, 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone
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別包装 |
あり
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純度 |
>=98%
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分子量 |
316.26
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CAS RN® |
480-19-3
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化合物の概要 |
Flavonol found in Tagetes.
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構造 |
C16H12O7
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溶媒 |
Soluble in acetone, methanol, ethylacetate, DMSO or water.
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使用目的 |
Isorhamnetin is a flavonol found in Tagetes that exhibits anti-obesity, anti-inflammatory, antioxidative, anticancer chemotherapeutic, and chemopreventive activities. Isorhamnetin decreases levels of PPARγ, CEBPα, LXRα, and lipoprotein lipase in adipocytes. In animal models of edema, isorhamnetin decreases expression of COX-2 and production of ROS and increases expression of Nrf2 and heme oxygenase 1 (HO-1). In colon cancer cells, isorhamnetin inhibits cell proliferation, induces G2/M phase cell cycle arrest, increases expression of cyclin B1, and inhibits signaling of the PI3K/Akt/mTOR pathway. Additionally, this compound decreases tumor development induced by DSS and azoxymethane in vivo by inhibiting activity of Src and β-catenin.
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その他 |
[融点]305℃ (dec.) [外観]White Powder
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参考文献 |
Seo K, Yang JH, Kim SC, et al. The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1. Inflammation. 2014 Jun;37(3):712-22. PMID: 24337631.Li C, Yang X, Chen C, et al. Isorhamnetin suppresses colon cancer cell growth through the PI3K Akt mTOR pathway. Mol Med Rep. 2014 Mar;9(3):935-40. PMID: 24398569.Saud SM, Young MR, Jones-Hall YL, et al. Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin. Cancer Res. 2013 Sep 1;73(17):5473-84. PMID: 23824743.Kim JE, Lee DE, Lee KW, et al. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. Cancer Prev Res (Phila). 2011 Apr;4(4):582-91. PMID: 21330379.Lee J, Jung E, Lee J, et al. Isorhamnetin represses adipogenesis in 3T3-L1 cells. Obesity (Silver Spring). 2009 Feb;17(2):226-32. PMID: 18948972.
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メーカー |
品番 |
包装 |
LKT
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I7357
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1 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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