別品名 |
MN-1695, Gaslon, 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate
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別包装 |
あり
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純度 |
>=98%
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分子量 |
372.17
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CAS RN® |
84504-69-8
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化合物の概要 |
NSAID; COX-1/2 and PDE inhibitor.
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構造 |
C9H7Cl2N5 C4H4O4
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溶媒 |
Soluble in DMSO.
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使用目的 |
Irsogladine exhibits anti-inflammatory, anti-fibrotic, and mucoprotective activities. Irsogladine decreases non-steroidal anti-inflammatory drug (NSAID)-induced intestinal mucosal injury, ulcers, and esophagitis; it inhibits COX-1 and COX-2. In animal models of colitis, irsogladine prevents DDS-induced increases in TGF-β1, collagen type 1, MMP2, TIMP-1, and α-SMA, preventing fibrosis. Additionally, irsogladine non-selectively inhibits phosphodiesterases, increasing cAMP and NO, facilitating gap junction communication and altering gastric mucosal blood flow.
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その他 |
[融点]289℃-294℃
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参考文献 |
Kuramoto T, Umegaki E, Nouda S, et al. Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study. BMC Gastroenterol. 2013 May 14;13:85. PMID: 23672202.Akagi M, Amagase K, Murakami T, et al. Irsogladine: overview of the mechanisms of mucosal protective and healing- promoting actions in the gastrointestinal tract. Curr Pharm Des. 2013;19(1):106-14. PMID: 22950502.Yamaguchi H, Suzuki K, Nagata M, et al. Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium. Med Mol Morphol. 2012 Jun;45(3):140-51. PMID: 23001296.
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メーカー |
品番 |
包装 |
LKT
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I7074
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100 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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