別品名 |
Biochanin B, Formononetol, Neochanin, 7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
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別包装 |
あり
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純度 |
>=90%
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分子量 |
268.26
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CAS RN® |
485-72-3
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化合物の概要 |
Isoflavone found in legumes such as soy.
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構造 |
C16H12O4
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溶媒 |
Soluble in DMSO (200mg/mL) or methanol (2mg/mL).
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使用目的 |
Formononetin is a phytoestrogen and isoflavone originally found in legumes in the Fabaceae family. Formononetin exhibits anti-inflammatory, antioxidative, anticancer, antihypertensive, anti-parasitic, anti-osteoporotic, and pro-angiogenic activities. Formononetin decreases expression of COX-2, malondialdehyde, TNF-α, and IL-6 and increases activity of superoxide dismutase and glutathione peroxidase in animal models of traumatic brain injury. In prostate cancer cells, formononetin increases expression of Bax and suppresses expression of IGF-1R, inducing apoptosis and inhibiting proliferation. In spontaneously hypertensive rats, formononetin decreases systolic blood pressure, increases expression of eNOS, and decreases expression of 5-HT receptors and α1-adrenergic receptors. Additionally, formononetin inhibits attachment and motility of Giardia. This compound also induces mesenchymal stem cell differentiation, increases expression of VEGF and VEGFR2, and promotes bone fracture healing.
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その他 |
[融点]258℃ [外観]Fine white powder
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参考文献 |
Li Z, Dong X, Zhang J, et al. Formononetin protects TBI rats against neurological lesions and the underlying mechanism. J Neurol Sci. 2014 Mar 15;338(1-2):112-7. PMID: 24411660.Huang WJ, Bi LY, Li ZZ, et al. Formononetin induces the mitochondrial apoptosis pathway in prostate cancer cells via downregulation of the IGF-1/IGF-1R signaling pathway. Pharm Biol. 2013 Dec 20. [Epub ahead of print]. PMID: 24359236.Sun T, Wang J, Huang LH, et al. Antihypertensive effect of formononetin through regulating the expressions of eNOS, 5-HT2A/1B receptors and α1-adrenoceptors in spontaneously rat arteries. Eur J Pharmacol. 2013 Jan 15;699(1-3):241-9. PMID: 23123056.Lauwaet T, Andersen Y, Van de Ven L, et al. Rapid detachment of Giardia lamblia trophozoites as a mechanism of antimicrobial action of the isoflavone formononetin. J Antimicrob Chemother. 2010 Mar;65(3):531-4. PMID: 20067984.Huh JE, Kwon NH, Baek YH, et al. Formononetin promotes early fracture healing through stimulating angiogenesis by up-regulating VEGFR-2/Flk-1 in a rat fracture model. Int Immunopharmacol. 2009 Nov;9(12):1357-65. PMID: 19695348.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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