別品名 |
(-)-3,3',4',5,5',7-Flavanhexol, Epigallocatechin, Epigallocatechol
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別包装 |
あり
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純度 |
>=98%
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分子量 |
306.27
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CAS RN® |
970-74-1
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化合物の概要 |
Flavanol originally found in Camilla (green tea); CB1 agonist.
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構造 |
C15H14O7
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溶媒 |
Soluble in water or alcohol.
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使用目的 |
(-)-Epigallocatechin (EGC) is a flavanol/catechin originally found in Camilla and other plan sources; it exhibits antioxidative, neuromodulatory, antithrombotic/anticoagulant, anticancer, anti-metastatic, and anti-osteoporotic activities. EGC displays agonist activity at cannabinoid 1 (CB1) receptors. In vivo, EGC inhibits platelet aggregation and increases activated partial thromboplastin time. Additionally, EGC inhibits expression of FLT3 and decreases phosphorylation of p38 MAPK, Akt, and STAT5 in acute myelogenous leukemia (AML) cells, suppressing cell proliferation. In breast cancer cells, EGC inhibits cell migration and invasion. This compound also decreases adipocyte formation, suppresses expression of PPARγ, CEBP, and FABP4, and increases osteogenic differentiation in vitro.
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その他 |
[融点]208-210 oC [外観]White Powder
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参考文献 |
Chen XQ, Wang XB, Guan RF, et al. Blood anticoagulation and antiplatelet activity of green tea (-)-epigallocatechin (EGC) in mice. Food Funct. 2013 Oct;4(10):1521-5. PMID: 24056410.Ly BT, Chi HT, Yamagishi M, et al. Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells. PLoS One. 2013 Jun 20;8(6):e66378. PMID: 23840454.Ko CH, Siu WS, Wong HL, et al. Pro-bone and antifat effects of green tea and its polyphenol, epigallocatechin, in rat mesenchymal stem cells in vitro. J Agric Food Chem. 2011 Sep 28;59(18):9870-6. PMID: 21877759.Korte G, Dreiseitel A, Schreier P, et al. Tea catechins' affinity for human cannabinoid receptors. Phytomedicine. 2010 Jan;17(1):19-22. PMID: 19897346.Kushima Y, Iida K, Nagaoka Y, et al. Inhibitory effect of (-)-epigallocatechin and (-)-epigallocatechin gallate against heregulin beta1-induced migration/invasion of the MCF-7 breast carcinoma cell line. Biol Pharm Bull. 2009 May;32(5):899-904. PMID: 19420761.
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メーカー |
品番 |
包装 |
LKT
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E6233
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5 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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