別品名 |
Adriacin, Adriblastina, Adriamycin, Caelyx, (8S-cis)10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo- hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11- trihydroxy-8-(hydroacetyl)-1-methoxy-5,12- naphthacenedione
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別包装 |
あり
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純度 |
>=98%
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分子量 |
579.99
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CAS RN® |
25316-40-9
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化合物の概要 |
Anthracycline, DNA intercalator; topoisomerase II inhibitor.
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構造 |
C27H29NO11 HCl
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溶媒 |
Soluble in water, methanol or aqueous alcohols. Soluble in DMSO to 10 mg/mL. Insoluble in acetone or chloroform.
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使用目的 |
Doxorubicin is an anthracycline that exhibits anticancer chemotherapeutic and anti-parasitic, antimalarial activities. Doxorubicin is a DNA intercalator that inhibits topoisomerase II and is clinically used to treat various cancers; it is part of the CHOP and ABVD chemotherapy regimens. Doxorubicin also promotes histone H2AX eviction from chromatin, limiting DNA repair mechanisms. Additionally, this compound inhibits growth of Plasmodium.
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その他 |
[融点]204℃-205℃(dec.) [外観]Orange-Red Crystal Powder
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参考文献 |
Pang B, Qiao X, Janssen L, et al. Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nat Commun. 2013;4:1908. PMID: 23715267.Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol. 2013 Feb;65(2):157-70. PMID: 23278683.Gamo FJ, Sanz LM, Vidal J, et al. Thousands of chemical starting points for antimalarial lead identification. Nature. 2010 May 20;465(7296):305-10. PMID: 20485427.Squillace RM, Miller D, Cookson M, et al. Antitumor activity of ridaforolimus and potential cell-cycle determinants of sensitivity in sarcoma and endometrial cancer models. Mol Cancer Ther. 2011 Oct;10(10):1959-1968. PMID: 21825008.
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メーカー |
品番 |
包装 |
LKT
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D5794
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10 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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