| 別品名 |
3,3'-Diindolymethane, 3,3'-Methylenebis-1H-indole, DIM
|
| 別包装 |
あり
|
| 純度 |
>=98%
|
| 分子量 |
246.31
|
| CAS RN® |
1968-05-4
|
| 化合物の概要 |
Indole found in cruciferous vegetables; AhR agonist.
|
| 構造 |
C17H14N2
|
| 溶媒 |
Soluble in DMSO (200 mg/mL). Insoluble in water.
|
| 使用目的 |
3,3’-Diindolylmethane (DIM) is found in cruciferous vegetables; it exhibits anti-inflammatory, immunosuppressive, antioxidative, anti-diabetic, anti-fibrotic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities. DIM acts as an agonist at the aryl hydrocarbon receptor. DIM increases levels of Foxp3 and function of Treg cells and decreases expression of toll-like receptor 4 (TLR4) and Th17 cells, preventing hepatic steatosis and inflammation in vivo. DIM also prevents the development of experimental autoimmune encephalitis (EAE) by suppressing T cell activity. In vivo, this compound decreases glucose levels, insulin levels, and Hb1Ac by increasing activity of glucokinase and glucose-6-phosphate dehydrogenase and decreasing activity of glucose-6-phosphatase and fructose-1,6-bisphosphatase. DIM also prevents the development of liver fibrosis in vivo. In cellular and animal models of nasopharyngeal carcinoma, DIM inhibits cellular invasion and metastasis and tumor growth; it also decreases activity of HDAC2.
|
| その他 |
[融点]163℃-165℃
[外観]Off white powder
|
| 参考文献 |
Liu Y, She W, Wang F, et al. 3, 3'-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. Int Immunopharmacol. 2014 Oct 1. [Epub ahead of print]. PMID: 25281898.Rouse M, Rao R, Nagarkatti M, et al. 3,3'-diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through microRNA signaling pathways. J Pharmacol Exp Ther. 2014 Aug;350(2):341-52. PMID: 24898268.Wu T, Chen C, Li F, et al. 3,3'-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition. Exp Ther Med. 2014 Jun;7(6):1635-1638. PMID: 24926357.Poornima J, Mirunalini S. Regulation of carbohydrate metabolism by indole-3-carbinol and its metabolite 3,3'-diindolylmethane in high-fat diet-induced C57BL/6J mice. Mol Cell Biochem. 2014 Jan;385(1-2):7-15. PMID: 24072613.Zhang Z, Gao Z, Hu W, et al. 3,3'-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression. Br J Pharmacol. 2013 Oct;170(3):649-60. PMID: 23902531.Chen C, Chen SM, Xu B, et al. In vivo and in vitro study on the role of 3,3'-diindolylmethane in treatment and prevention of nasopharyngeal carcinoma. Carcinogenesis. 2013 Aug;34(8):1815-21. PMID: 23568953.Beaver LM, Yu TW, Sokolowski EI, et al. 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol. 2012 Sep 15;263(3):345-51. PMID: 22800507.Cho HJ, Seon MR, LLee YM, et al. 3,3'-Diindolylmethane suppresses the inflammatory response to lipopolysacharide in murine macrophages. J Nutr. 2008 Jan;138(1):17-23. PMID: 18156398.
|
|
※サムネイル画像をクリックすると拡大画像が表示されます。
|
|
|
|
※表示価格について
| 当社在庫 |
なし
|
| 納期目安 |
1週間程度
|
| 保存温度 |
常温
|
|
