別品名 |
2-Propenyl sulphide, 3,3-Thiobis(1-propene), Diallyl monosulfide, Diallyl thioether, Allyl monosulfide, Allyl sulfide, Di-2-propenyl sulfide
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別包装 |
あり
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純度 |
>=97%
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分子量 |
114.21
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CAS RN® |
592-88-1
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化合物の概要 |
Organosulfur found in garlic.
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構造 |
C6H10S
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溶媒 |
Insoluble in water.
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使用目的 |
Diallyl sulfide is an organosulfur initially found in garlic; it exhibits anticancer chemotherapeutic, chemopreventive, neuroprotective, anti-inflammatory, antioxidative, anti-angiogenic, and anti-metastatic activities. Diallyl sulfide decreases DES-induced DNA damage and carcinogenesis in vitro and in vivo; it also inhibits the development of colon polyps in other carcinogenesis models. In animal models of cerebral ischemia/reperfusion, diallyl sulfide decreases infarct volume, apoptosis, and caspase 3 activation and increases levels of Bcl-2. In vitro, this compound decreases TNF-α-induced activation of NF-κB and suppresses histamine-induced levels of ROS, IL-1β, and TNF-α. Like other organosulfurs, diallyl sulfide induces phase II enzymes, increasing glutathione-S-transferase, glutathione reductase, superoxide dismutase, catalase, glutathione peroxidase, and Nrf2 in vivo. In animal models of osteosarcoma, diallyl sulfide decreases VEGF levels, microvessel density, cellular invasion, and tumor growth.
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その他 |
[融点]-83℃ [外観]Clear, Colorless liquid[沸点]138℃
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参考文献 |
McCaskill ML, Rogan E, D Thomas R. Diallyl sulfide inhibits diethylstilbestrol induced DNA damage in human breast epithelial cells (MCF-10A). Steroids. 2014 Sep 30. [Epub ahead of print]. PMID: 25278253.Ho CY, Weng CJ, Jhang JJ, et al. Diallyl sulfide as a potential dietary agent to reduce TNF-α- and histamine-induced proinflammatory responses in A7r5 cells. Mol Nutr Food Res. 2014 May;58(5):1069-78. PMID: 24415531.Hu Y, Chen L, Yi C, et al. Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma MG-63 cells. J Huazhong Univ Sci Technolog Med Sci. 2012 Aug;32(4):581-5. PMID: 22886974.Kang JS, Kim TM, Shim TJ, et al. Modifying effect of diallyl sulfide on colon carcinogenesis in C57BL/6J-ApcMin/+ mice. Asian Pac J Cancer Prev. 2012;13(4):1115-8. PMID: 22799291.Lin X, Yu S, Chen Y, et al. Neuroprotective effects of diallyl sulfide against transient focal cerebral ischemia via anti-apoptosis in rats. Neurol Res. 2012 Jan;34(1):32-7. PMID: 22196859.Ho CY, Cheng YT, Chau CF, et al. Effect of diallyl sulfide on in vitro and in vivo Nrf2-mediated pulmonic antioxidant enzyme expression via activation ERK/p38 signaling pathway. J Agric Food Chem. 2012 Jan 11;60(1):100-7. PMID: 22118872.
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メーカー |
品番 |
包装 |
LKT
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D3201
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25 ML
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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