別品名 |
Cyclosporine, Ciclosporin, Sandimmun, Neoral
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別包装 |
あり
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純度 |
>=98%
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分子量 |
1202.61
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CAS RN® |
59865-13-3
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化合物の概要 |
Cyclic peptide; calcineurin inhibitor.
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構造 |
C62H111N11O12
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溶媒 |
Soluble in methanol, ethanol, acetone, ether or chloroform. Very slightly soluble in water.
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使用目的 |
Cyclosporin A is a cyclic peptide that exhibits immunosuppressive activity. Cyclosporin A is clinically used to prevent rejection in organ transplants and to treat or prevent graft-versus-host disease (GvHD). Cyclosporin A binds cyclophilin, inhibiting calcineurin and decreasing levels of IL-2 and activated T cells. Cyclosporin A also shows benefit in the treatment of traumatic brain injury.
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その他 |
[融点]148℃-151℃ [外観]White Crystal Powder
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参考文献 |
Lulic D, Burns J, Bae EC, et al. A review of laboratory and clinical data supporting the safety and efficacy of cyclosporin A in traumatic brain injury. Neurosurgery. 2011 May;68(5):1172-86. PMID: 21307793.Reynolds NJ, Al-Daraji WI. Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology. Clin Exp Dermatol. 2002 Oct;27(7):555-61. PMID: 12464150.Handschumacher RE, Harding MW, Rice J, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7. PMID: 6238408.Koseki N, Deguchi J, Yamashita A, et al. Establishment fo a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish. J Toxicol Sci. 2014 Aug;39(4):579-600. PMID: 25056783.
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[注意事項] |
【安衛法】この商品は、労働安全衛生法で定めるがん原性物質を含みます。
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メーカー |
品番 |
包装 |
LKT
|
C9611
|
100 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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法規制 |
安
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保存温度 |
常温
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