別品名 |
N-[(7S)-5,6,7,9-Tetrahydro-1,10,3,10-tetramethoxy-9- oxobenzo[a]heptalen-7-yl]acetamide
|
別包装 |
あり
|
純度 |
>=97%
|
分子量 |
399.44
|
CAS RN® |
64-86-8
|
化合物の概要 |
Found in Colchicum; microtubule polymerization inhibitor.
|
構造 |
C22H25NO6
|
溶媒 |
Soluble in water (40 mg/mL), ethanol (7 mg/ml), DMSO (14 mg/ml), or chloroform. Insoluble in petr. ether.
|
使用目的 |
Colchicine is an anti-inflammatory anti-mitotic compound originally found in Colchicum; it is clinically used to treat gout. Colchicine binds tubulin and inhibits microtubule polymerization, inhibiting inflammasome activation, cytokine generation, and chemotaxis. Colchicine inhibits neutrophil motility. The anticancer potential of colchicine is limited by its high toxicity.
|
その他 |
[融点]142℃-150℃ [外観]Faintly yellow crystal powder
|
参考文献 |
Dalbeth N, Lauterio TJ, Wolfe HR. Mechanism of Action of Colchicine in the Treatment of Gout. Clin Ther. 2014 Aug 21. [Epub ahead of print]. PMID: 25151572.Ching JK, Ju JS, Pittman SK, et al. Increased autophagy accelerates colchicine-induced muscle toxicity. Autophagy. 2013 Dec;9(12):2115-25. PMID: 24184927.
|
※サムネイル画像をクリックすると拡大画像が表示されます。
|
|
|
メーカー |
品番 |
包装 |
LKT
|
C5645
|
500 MG
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
4℃
|
|