別品名 |
7(S)-Chloro-7-deoxylincomycin hydrochloride, Cleocin hydrochloride, Dalacina
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別包装 |
あり
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純度 |
>=98%
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分子量 |
461.44
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CAS RN® |
21462-39-5
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化合物の概要 |
Lincosamide; ribosomal translocation and protein synthesis inhibitor.
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構造 |
C18H34Cl2N2O5S HCl
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溶媒 |
Soluble in water (50 mg/mL), alcohol, DMF, DMSO (45 mg/mL).
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使用目的 |
Clindamycin is a lincosamide antibiotic that exhibits antibacterial, anti-protozoan, anti-parasitic, and antimalarial activities. Clindamycin displays efficacy against anaerobic gram negative bacteria, Streptococcus, and Staphylococcus (particularly MRSA). Clindamycin binds 23S rRNA of the ribosomal 50S subunit, preventing translocation and protein synthesis. When co-administered with other anti-parasitic compounds, clindamycin is also occasionally used to treat Plasmodium infection.
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その他 |
[融点]141-143℃ [外観]White Crystal Powder
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参考文献 |
Takem EN, D'Alessandro U. Malaria in pregnancy. Mediterr J Hematol Infect Dis. 2013;5(1):e2013010. PMID: 23350023.Sireesha P, Setty CR. Detection of various types of resistance patterns and their correlation with minimal inhibitory concentrations against clindamycin among methicillin-resistant Staphylococcus aureus isolates. Indian J Med Microbiol. 2012 Apr-Jun;30(2):165-9. PMID: 22664431.Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523.Schlunzen F, Zarivach R, Harms J, et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. PMID: 11677599.
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メーカー |
品番 |
包装 |
LKT
|
C4532
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100 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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