別品名 |
Celexa, Cipramil, Elopram, Seropram., (RS)-1-[3-(dimethylamino)propyl]-1-(p-flurophenyl)- 5-phthalancarbonitrile, hydrobromide
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別包装 |
あり
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純度 |
>=98%
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分子量 |
405.31
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CAS RN® |
59729-32-7
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化合物の概要 |
SERT inhibitor.
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構造 |
C20H21FN2O HB4
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溶媒 |
DMSO (18 mg/ml)Water (4 mg/ml)Ethanol (20 mg/ml)
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使用目的 |
Citalopram is a selective serotonin reuptake inhibitor (SSRI) that inhibits the serotonin transporter (SERT); citalopram is clinically used for its antidepressant and anxiolytic activities, although it may prolong the QT interval. The S-isomer of citalopram is active and is sold on its own as escitalopram. Citalopram also exhibits neuroprotective activity, increasing expression of BDNF and inhibiting neuronal apoptosis. Additionally, this compound displays anti-inflammatory benefit, inhibiting arthritis progression in vivo by suppressing TLR signaling and decreasing production of TNF, IL-6, and IFN-γ.
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その他 |
[融点]182℃-183℃
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参考文献 |
Tan Y, Duan J, Li Y, et al. Effects of citalopram on serum deprivation induced PC12 cell apoptosis and BDNF expression. Pharmazie. 2010 Nov;65(11):845-8. PMID: 21155393.Sacre S, Medghalchi M, Gregory B, et al. Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors. Arthritis Rheum. 2010 Mar;62(3):683-93. PMID: 20131240.Apparsundaram S, Stockdale DJ, Henningsen RA, et al. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. J Pharmacol Exp Ther. 2008 Dec;327(3):982-90. PMID: 18801947.
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メーカー |
品番 |
包装 |
LKT
|
C3477
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25 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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法規制 |
劇
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保存温度 |
常温
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