別品名 |
Toddaline, 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium
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別包装 |
あり
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純度 |
>=98%
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分子量 |
383.82
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CAS RN® |
3895-92-9
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化合物の概要 |
benzophenanthridine alkaloid found in Chelidonium and Zanthoxylum; PKC and Na+/K+ ATPase inhibitor.
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構造 |
C21H18ClNO4
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溶媒 |
Soluble in DMSO.
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使用目的 |
Chelerythrine is a benzophenanthridine alkaloid found in Chelidonium and Zanthoxylum that exhibits anti-inflammatory and anticancer activities. Chelerythrine inhibits PKC and Na+/K+ ATPases. In LPS-stimulated animal models, chelerythrine decreases levels of TNF-α, IL-6, and myeloperoxidase. In hepatoma cells, this compound decreases the mitochondrial membrane potential, increases release of cytochrome C, stimulates cleavage of PARP, alters the Bax/Bcl-xl ratio, and induces apoptosis.
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その他 |
[融点]207℃ [外観]Yellow Powder
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参考文献 |
Niu X, Mu Q, Li W, et al. Protective Effects of Chelerythrine Against Lipopolysaccharide-Induced Endotoxic Shock in Mice. Inflammation. 2014 Jun 14. [Epub ahead of print]. PMID: 24928629.Dorney KM, Sizemore IE, Alqahtani T, et al. Surface-enhanced Raman spectroscopy (SERS) tracking of chelerythrine, a Na(+)/K(+) pump inhibitor, into cytosol and plasma membrane fractions of human lens epithelial cell cultures. Cell Physiol Biochem. 2013;32(7):146-56. PMID: 24429821.Zhang ZF, Guo Y, Zhang JB, et al. Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell. Arch Pharm Res. 2011 May;34(5):791-800. PMID: 21656365.
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メーカー |
品番 |
包装 |
LKT
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C2818
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1 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
-20℃
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