Brefeldin A  

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別品名 Ascotoxin, Cyanein, Decumbin, 1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy- 6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
別包装 あり
純度 >=97%
分子量 280.36
CAS RN® 20350-15-6
化合物の概要 Lactone found in fungi such as Eupenicillium; guanine nucleotide exchange factor inhibitor.
構造 C16H24O4
溶媒 Soluble in methanol.
使用目的 Brefeldin A is a lactone antibiotic found in fungi such as Eupenicillium; it exhibits anticancer and antiviral activities. Brefeldin A inhibits activity of guanine nucleotide exchange factors, preventing association with COPI and COPI-mediated vesicle formation and suppressing protein transport from the endoplasmic reticulum to the Golgi apparatus. Brefeldin A is used in research models to study endoplasmic reticulum stress and protein transport. In vitro, this compound inhibits poliovirus replication. In prostate cancer cells, brefeldin A inhibits cell growth, induces apoptosis and G1 phase cell cycle arrest, decreases levels of p53, CDK2, CDK4, and cyclin D1, and causes cell death.
その他 [融点]204℃-205℃
[外観]White Crystal Powder
参考文献 Zhou C, Li C, Li D, et al. BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein regulates neurite development via PI3K-AKT and ERK signaling pathways. Neuroscience. 2013 Dec 19;254:361-8. PMID: 24090963.Rouhana J, Padilla A, Estaran S, et al. Kinetics of interaction between ADP-ribosylation factor-1 (Arf1) and the Sec7 domain of Arno guanine nucleotide exchange factor, modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A. J Biol Chem. 2013 Feb 15;288(7):4659-72. PMID: 23255605.Chapman JR, Tazaki H, Mallouh C, et al. Brefeldin A-induced apoptosis in prostatic cancer DU-145 cells: a possible p53-independent death pathway. BJU Int. 1999 Apr;83(6):703-8. PMID: 10233583.Cuconati A, Molla A, Wimmer E. Brefeldin A inhibits cell-free, de novo synthesis of poliovirus. J Virol. 1998 Aug;72(8):6456-64. PMID: 9658088.


メーカー 品番 包装
LKT B6816 10 MG
希望販売価格 ¥23,000


当社在庫 なし
納期目安 1週間程度
保存温度 -20℃




メーカー名 LKT Laboratories, Inc.
略号 LKT