別品名 |
Ascotoxin, Cyanein, Decumbin, 1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy- 6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
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別包装 |
あり
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純度 |
>=97%
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分子量 |
280.36
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CAS RN® |
20350-15-6
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化合物の概要 |
Lactone found in fungi such as Eupenicillium; guanine nucleotide exchange factor inhibitor.
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構造 |
C16H24O4
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溶媒 |
Soluble in methanol.
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使用目的 |
Brefeldin A is a lactone antibiotic found in fungi such as Eupenicillium; it exhibits anticancer and antiviral activities. Brefeldin A inhibits activity of guanine nucleotide exchange factors, preventing association with COPI and COPI-mediated vesicle formation and suppressing protein transport from the endoplasmic reticulum to the Golgi apparatus. Brefeldin A is used in research models to study endoplasmic reticulum stress and protein transport. In vitro, this compound inhibits poliovirus replication. In prostate cancer cells, brefeldin A inhibits cell growth, induces apoptosis and G1 phase cell cycle arrest, decreases levels of p53, CDK2, CDK4, and cyclin D1, and causes cell death.
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その他 |
[融点]204℃-205℃ [外観]White Crystal Powder
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参考文献 |
Zhou C, Li C, Li D, et al. BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein regulates neurite development via PI3K-AKT and ERK signaling pathways. Neuroscience. 2013 Dec 19;254:361-8. PMID: 24090963.Rouhana J, Padilla A, Estaran S, et al. Kinetics of interaction between ADP-ribosylation factor-1 (Arf1) and the Sec7 domain of Arno guanine nucleotide exchange factor, modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A. J Biol Chem. 2013 Feb 15;288(7):4659-72. PMID: 23255605.Chapman JR, Tazaki H, Mallouh C, et al. Brefeldin A-induced apoptosis in prostatic cancer DU-145 cells: a possible p53-independent death pathway. BJU Int. 1999 Apr;83(6):703-8. PMID: 10233583.Cuconati A, Molla A, Wimmer E. Brefeldin A inhibits cell-free, de novo synthesis of poliovirus. J Virol. 1998 Aug;72(8):6456-64. PMID: 9658088.
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メーカー |
品番 |
包装 |
LKT
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B6816
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5 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
-20℃
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