別品名 |
4'-Methylgenistein, Biochanin
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別包装 |
あり
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純度 |
>=98%
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分子量 |
284.27
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CAS RN® |
491-80-5
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化合物の概要 |
Phytoestrogen, flavonoid found in clover, soy, and alfalfa; potential PPARα and PPARγ agonist.
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構造 |
C16H12O5
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溶媒 |
Soluble in acetone, chloroform, methanol, DMSO (55 mg/mL), ethanol (9 mg/mL).
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使用目的 |
Biochanin A is an isoflavone/flavonoid found in plants in the Fabaceae family, such as clover, soy, and alfalfa. Biochanin A exhibits anticancer, anti-metastatic, estrogenic, neuroprotective, anti-osteoporotic, antiviral, and anti-inflammatory activities. Biochanin A may activate PPARα and PPARγ. In pancreatic cancer cells, biochanin A inhibits cellular proliferation, migration, and invasion, and suppresses activation of Akt and MAPKs. In other cellular models, biochanin A acts as a phytoestrogen and increases expression of ERβ. Biochanin A also improves cognitive deficits in animal models of Alzheimer’s disease. In stem cells, this compound inhibits adipocyte differentiation and increases osteoblast differentiation. Additionally, biochanin A inhibits replication of influenza virus and suppresses production of IL-6, IL-8, IL-10, and TNF-α in vitro.
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その他 |
[融点]210℃-213℃ [外観]White Crystal Powder
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参考文献 |
Wang L, Waltenberger B, Pferschy-Wenzig EM, et al. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Biochem Pharmacol. 2014 Jul 30. [Epub ahead of print]. PMID: 25083916.Biradar SM, Joshi H, Chheda TK. Biochanin-A ameliorates behavioural and neurochemical derangements in cognitive-deficit mice for the betterment of Alzheimer's disease. Hum Exp Toxicol. 2014 Apr;33(4):369-82. PMID: 23900307.Bhardwaj V, Tadinada SM, Jain A, et al. Biochanin A reduces pancreatic cancer survival and progression. Anticancer Drugs. 2014 Mar;25(3):296-302. PMID: 24201306.Nynca A, Swigonska S, Piasecka J, et al. Biochanin A affects steroidogenesis and estrogen receptor-β expression in porcine granulosa cells. Theriogenology. 2013 Oct 15;80(7):821-8. PMID: 23953692.Su SJ, Yeh YT, Su SH, et al. Biochanin a promotes osteogenic but inhibits adipogenic differentiation: evidence with primary adipose-derived stem cells. Evid Based Complement Alternat Med. 2013;2013:846039. PMID: 23843885.Sithisarn P, Michaelis M, Schubert-Zsilavecz M, et al. Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells. Antiviral Res. 2013 Jan;97(1):41-8. PMID: 23098745.
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メーカー |
品番 |
包装 |
LKT
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B3358
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250 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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