| 別品名 |
Isothiocyanic acid benzyl ester, 2-Bromo-4-trifluoro- methyl-6-nitrophenyl-isothiocyanate, Benzene, (isothiocyanatomethyl)-
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| 別包装 |
あり
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| 純度 |
>=97%
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| 分子量 |
149.22
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| CAS RN® |
622-78-6
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| 化合物の概要 |
ITC found in cruciferous vegetables.
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| 構造 |
C8H7NS
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| 溶媒 |
Soluble in DMSO, ethanol, chloroform.
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| 使用目的 |
Benzyl isothiocyanate (BITC) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities. BITC inhibits IL-13 expression in basophils. BITC induces phase II enzymes, increasing levels of heme oxygenase 1 (HO-1), glutathione, and glutamate cysteine ligase; it also decreases levels of ROS, activation of NF-κB, adhesion of monocytes, and expression of ICAM-1, VCAM-1, and E-selectin. This compound inhibits growth of Trypanosoma and displays antibacterial efficacy against Campylobacter by disrupting metabolic processes. In vitro and in vivo, BITC decreases high fat diet-induced tumor growth and multiplicity, also inhibiting macrophage migration and lipid droplet accumulation. This compound inhibits squamous cell carcinoma cell invasion and migration and induces apoptosis and autophagy in prostate cancer cells. In various animal models, BITC inhibits development of mammary gland tumors and decreases activation of STAT3 and secretion of VEGF, MMP-2, and HIF-1α.
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| その他 |
[融点]41o C
[外観]Clear Light Yellow Liquid[沸点]242℃-243℃
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| 参考文献 |
Tang Y, Abe N, Yoshimoto M, et al. Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells. Biosci Biotechnol Biochem. 2014 Sep 25:1-5. PMID: 25253661.Kim M, Cho HJ, Kwon GT, et al. Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression via the alteration of tumor microenvironments in obesity-resistant BALB/c mice. Mol Carcinog. 2014 Apr 11. [Epub ahead of print]. PMID: 24729546.Steverding D, Michaels S, Read KD. In vitro and in vivo studies of trypanocidal activity of dietary isothiocyanates. Planta Med. 2014 Feb;80(2-3):183-6. PMID: 24452460.Dufour V, Stahl M, Rosenfeld E, et al. Insights into the mode of action of benzyl isothiocyanate on Campylobacter jejuni. Appl Environ Microbiol. 2013 Nov;79(22):6958-68. PMID: 24014524.Huang CS, Lin AH, Liu CT, et al. Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFκB activation. Mol Nutr Food Res. 2013 Nov;57(11):1918-30. PMID: 23836589.Lin JF, Tsai TF, Liao PC, et al. Benzyl isothiocyanate induces protective autophagy in human prostate cancer cells via inhibition of mTOR signaling. Carcinogenesis. 2013 Feb;34(2):406-14. PMID: 23172666.Boreddy SR, Sahu RP, Srivastava SK. Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3. PLoS One. 2011;6(10):e25799. PMID: 22016776.Warin R, Chambers WH, Potter DM, et al. Prevention of mammary carcinogenesis in MMTV-neu mice by cruciferous vegetable constituent benzyl isothiocyanate. Cancer Res. 2009 Dec 15;69(24):9473-80. PMID: 19934325.Kim SH, Nagalingam A, Saxena NK, et al. Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3. Carcinogenesis. 2011 Mar;32(3):359-367. PMID: 21163886.
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※表示価格について
| 当社在庫 |
なし
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| 納期目安 |
1週間程度
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| 保存温度 |
４℃
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