| 別品名 |
Azitrocin, Ribotrex, Sumamed, Zithromax, Zitromax, [2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,- 14R*)]-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α- L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3- (dimethylamio)-β-D-xylo-hexopyranosyl]oxy]-1-oxa- 6-azacyclopentadecan-15-one
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| 別包装 |
あり
|
| 標識物 |
Unlabeled
|
| 純度 |
>=98%
|
| 分子量 |
785.02
|
| CAS RN® |
117772-70-0
|
| 化合物の概要 |
Azalide macrolide; protein translation inhibitor.
|
| 構造 |
C38H72N2O12 2H2O
|
| 溶媒 |
Slightly soluble in water. DMSO:100 mg/mL, Ethanol:100 mg/mL.
|
| 使用目的 |
Azithromycin is an azalide macrolide antibiotic derived from erythromycin. Azithromycin binds the bacterial 50S ribosomal subunit, inhibiting protein translation. Azithromycin displays antibacterial, anti-fibrotic, and anti-inflammatory activities. In epithelial cells, azithromycin inhibits the epithelial-to-mesenchymal transition (EMT) by inhibiting expression of Smad3. Additionally, azithromycin inhibits production of arachidonic acid, eicosanoids, IL-6, and IL-12 in LPS-stimulated macrophages.
|
| その他 |
[融点]113℃ -115℃
[外観]White Crystal Powder
|
| 参考文献 |
Bakheit AH, Al-Hadiya BM, Abd-Elgalil AA. Azithromycin. Profiles Drug Subst Excip Relat Methodol. 2014;39:1-40. PMID: 24794904.Medina CA, Rowe AM, Yun H, et al. Azithromycin treatment increases survival of high-risk corneal allotransplants. Cornea. 2013 May;32(5):658-66. PMID: 23407315.Banerjee B, Musk M, Sutanto EN, et al. Regional differences in susceptibiity of bronchial epithelium to mesenchymal transition and inhibition by the macrolide antibiotic azithromycin. PLoS One. 2012;7(12):e52309. PMID: 23284981.Banjanac M, Munic Kos V, Nujic K, et al. Anti-inflammatory mechanism of action of azithromycin in LPS-stimulated J774A.1 cells. Pharmacol Res. 2012 Oct;66(4):357-62. PMID: 22766077.Togami K, Chono S, Morimoto K. Distribution characteristics of clarithromycin and azithromycin, macrolide antimicrobial agents used for treatment of respiratory infections, in lung epithelial lining fluid and alveolar macrophages. Biopharm Drug Dispos. 2011 Oct;32(7):389-397. PMID: 21812004.
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| メーカー |
品番 |
包装 |
|
LKT
|
A9834
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500 MG
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※表示価格について
| 当社在庫 |
なし
|
| 納期目安 |
1週間程度
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| 保存温度 |
常温
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