別品名 |
Artemisine, Arteannuin, Quinghaosu, QHS, (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-tri- methyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzo- dioxepin-10(3H)-one
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別包装 |
あり
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純度 |
>=98%
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分子量 |
282.35
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CAS RN® |
63968-64-9
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化合物の概要 |
Sesquiterpene lactone found in Artemisia (wormwood).
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構造 |
C15H22O5
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溶媒 |
Insoluble in water. Soluble in methanol (24mg/ml), acetone, ethanol, DMF, DMSO (57 mg/ml) at 25° C, acetone, chloroform (25 mg/ml), DCM, and ethyl acetate;
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使用目的 |
Artemisinin is a sesquiterpene lactone originally found in Artemisia (wormwood); it is clinically used to treat malaria. Artemisinin exhibits anti-parasitic, antimalarial, cardioprotective, anticancer, and anti-inflammatory activities. This compound inhibits growth of Plasmodium. In animal models of myocardial infarction, artemisinin decreases ventricular fibrillation threshold and levels of TNF-α and increases expression of connexin 43. In macrophages, this compound inhibits IL-6 release. Artemisinin also inhibits growth of neuroblastoma cells, increasing activation of AMPK and decreasing signaling by mTOR.
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その他 |
[融点]156℃-157℃ [外観]White crystalline solid
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参考文献 |
Gu Y, Wu G, Wang X, et al. Artemisinin prevents electric remodeling following myocardial infarction possibly by upregulating the expression of connexin 43. Mol Med Rep. 2014 Oct;10(4):1851-6. PMID: 25110145.Tan WQ, Chen G, Jia B, et al. Artemisinin inhibits neuroblastoma proliferation through activation of AHP-activated protein kinase (AMPK) signaling. Pharmazie. 2014 Jun;69(6):468-72. PMID: 24974584.Patel K, Batty KT, Moore BR, et al. Predicting the parasite killing effect of artemisinin combination therapy in a murine malaria model. J Antimicrob Chemother. 2014 Aug;69(8):2155-63. PMID: 24777899.Yu WY, Kan WJ, Yu PX, et al. Anti-inflammatory effect and mechanism of artemisinin and dihydroartemisinin. Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2618-21. PMID: 23236763.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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