別品名 |
Apigenine, Apigenol, Chamomile, Spigenin, Versulin, 5,7-dihydroxy-2-(4-hydroxyphenyl)-(9CI)-4H- 1-Benzopyran-4-one
|
別包装 |
あり
|
純度 |
>=98%
|
分子量 |
270.24
|
CAS RN® |
520-36-5
|
化合物の概要 |
Flavonoid found in various plant sources; GABA-A positive modulator, potential microtubule depolymerization inducer.
|
構造 |
C15H10O5
|
溶媒 |
Moderately soluble in hot alcohol. Soluble in dilute KOH.
|
使用目的 |
Apigenin is a flavonoid found in various plant sources that exhibits anticancer, antioxidative, anti-inflammatory, cognition enhancing, and neuroprotective activities. In gastric cancer cells, apigenin inhibits cell proliferation, decreases mitochondrial membrane potential, increases expression of caspase 3 and Bax, and decreases expression of Bcl-2, inducing apoptosis. Apigenin also induces microtubule depolymerization in lung cancer cells. Additionally, apigenin displays some chemopreventive potential. In aortic rings, apigenin inhibits vascular contraction. In animal models of spinal cord injury, apigenin reverses injury-induced decreases in superoxide dismutase (SOD) and glutathione peroxidase activity as well as increases in malondialdehyde; it also decreases expression of IL-1β, TNF-α, and ICAM-1. In animal models of Alzheimer’s disease, apigenin suppresses oxidative stress and decreases levels of insoluble amyloid-β (Aβ), ameliorating learning and cognitive deficits. Additionally, this compound acts as a positive allosteric modulator at GABA-A receptors.
|
その他 |
[融点]345℃-350℃
|
参考文献 |
Chen J, Chen J, Li Z, et al. The apoptotic effect of apigenin on human gastric carcinoma cells through mitochondrial signal pathway. Tumour Biol. 2014 May 8. [Epub ahead of print]. PMID: 24805829.Zhang F, Li F, Chen G. Neuroprotective effect of apigenin in rats after contusive spinal cord injury. Neurol Sci. 2014 Apr;35(4):583-8. PMID: 24166720.Je HD, Kim HD, La HO. The Inhibitory Effect of Apigenin on the Agonist-Induced Regulation of Vascular Contractility via Calcium Desensitization-Related Pathways. Biomol Ther (Seoul). 2014 Feb;22(2):100-5. PMID: 24753814.Zhao L, Wang JL, Liu R, et al. Neuroprotective, anti-amyloidogenic and neurotrophic effects of apigenin in an Alzheimer's disease mouse model. Molecules. 2013 Aug 19;18(8):9949-65. PMID: 23966081.Choudhury D, Ganguli A, Dastidar DG, et al. Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin. Biochimie. 2013 Jun;95(6):1297-309. PMID: 23485682.Li Y, Xu J, Zhu G, et al. Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity. Cell Death Discov. 2018 Nov 20;4:105. PMID: 30479839.
|
※サムネイル画像をクリックすると拡大画像が表示されます。
|
|
|
メーカー |
品番 |
包装 |
LKT
|
A6234
|
100 MG
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
常温
|
|