別品名 |
α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, ACIA, (2S)-2-amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
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別包装 |
あり
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純度 |
>=98%
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分子量 |
178.57
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CAS RN® |
42228-92-2
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化合物の概要 |
Glutamine analog; γ-glutamyl transferase, CTP synthetase, GMP synthetase, FGAM synthetase inhibitor.
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構造 |
C5H7ClN2O3
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溶媒 |
Soluble in water to 18mg/mL. Slightly soluble in methanol, ethanol or chloroform.
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使用目的 |
Acivicin is a fermentation product of Streptomyces; it is a glutamine analog. Acivicin inhibits γ-glutamyl transferase, CTP synthetase, GMP synthetase, and FGAM synthetase, preventing purine synthesis. Acivicin exhibits anticancer and antifungal activity, although its potential chemotherapeutic benefit is limited by high CNS toxicity. Acivicin inhibits the growth of pancreatic cancer cells and, separately, the growth of Alternaria, Magnaporthe, and Botrytis.
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その他 |
[融点]209℃-211℃ [外観]White to off white powder
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参考文献 |
Maeda K, Nakajima Y, Motoyama T, et al. Effects of acivicin on growth, mycotoxin production and virulence of phytopathogenic fungi. Lett Appl Microbiol. 2014 May 27. [Epub ahead of print]. PMID: 24863673.Hidalgo M, Rodriguez G, Kuhn JG, et al. Clin Cancer Res. 1998 Nov;4(11):2763-70. PMID: 9829740.Lyons SD, Sant ME, Christopherson RI. Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia. J Biol Chem. 1990 Jul 5;265(19):11377-81. PMID: 2358467.Allen L, Meck R, Yunis A. The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501). Res Commun Chem Pathol Pharmacol. 1980 Jan;27(1):175-82. PMID: 6102405.
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メーカー |
品番 |
包装 |
LKT
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A0934
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100 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
-20℃
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