別包装 |
あり
|
純度 |
>=98%
|
分子量 |
376.43
|
CAS RN® |
133343-34-7
|
化合物の概要 |
Found in Streptomyces; proteasome inhibitor.
|
構造 |
C15H24N2O7S
|
溶媒 |
Soluble DMSO or water.
|
使用目的 |
Lactacystin is a proteasome inhibitor initially produced by Streptomyces that exhibits hepatoprotective, anti-metastatic, and anticancer chemotherapeutic activities. Lactacystin increases the Bax/Bcl-2 ratio and inhibits proliferation of cells and growth of tumors in models of glioma. Additionally, lactacystin inhibits growth and migration of smooth muscle cells. In animal models of intestinal ischemia/reperfusion-induced liver injury, lactacystin inhibits activation of NF-κB, suppresses infiltration of neutrophils, and decreases levels of ICAM-1.
|
その他 |
[外観]White Solid
|
参考文献 |
Wang H, Zhang S, Zhong J, et al. The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: an in vitro and in vivo study. J Int Med Res. 2013 Feb;41(1):72-81. PMID: 23569132.Barringhaus KG, Matsumura ME. The proteasome inhibitor lactacystin attenuates growth and migration of vascular smooth muscle cells and limits the response to arterial injury. Exp Clin Cardiol. 2007 Fall;12(3):119-24. PMID: 18650992.Yao JH, Li YH, Wang ZZ, et al. Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion. Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1102-8. PMID: 17880361.
|
※サムネイル画像をクリックすると拡大画像が表示されます。
|
|
|
メーカー |
品番 |
包装 |
LKT
|
L0107
|
1 MG
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
-20℃
|
|