Tetracycline Hydrochloride  

別品名 Achromycin, Panmycin, Topicycline, Cylcopar, Diocyclin, [4S-(4α, 4aα, 5aα,6β,12aα)]-4-(Dimethylamino)- 1,4,4a,5,5a,6-11,12a-octahydro-3,6,10,12,12a-penta- hydroxy-6-methyl-1,11-dioxo-2-naphthacene- carboxamide hydrochloride
別包装 あり
純度 >=96%
分子量 480.9
CAS RN® 64-75-5
化合物の概要 Polyketide; protein translation inhibitor, mammalian RNA splicing inhibitor, potential MMP inhibitor.
構造 C22H24N2O8 HCl
溶媒 Soluble in water (100 mg/mL), methanol and ethanol (10 mg/mL). Insoluble in ether and hydrocarbons.
使用目的 Tetracycline is a polyketide antibiotic originally produced by Streptomyces that exhibits antibacterial and neuroprotective activities. Tetracycline binds the 30S subunit of the bacterial ribosome, preventing aminoacyl-tRNA from binding to the ribosomal A site and inhibiting protein synthesis. Tetracycline is clinically used to treat acne, rosacea, Lyme disease, and various bacterial infections. Tetracycline binds amyloid-β (Aβ) peptides, increasing their solubility and decreasing their neurotoxicity in vitro. Tetracycline may also inhibit matrix metalloproteinases (MMPs). Additionally, tetracycline inhibits mammalian RNA splicing.
その他 [融点]220℃-223℃
[外観]Yellow Crystalline Powder
参考文献 Kennedy R, Alibhai M, Shakib K. Tetracycline: a cure all? Br J Oral Maxillofac Surg. 2014 Apr;52(4):382-3. PMID: 24613100.Mahajan GB, Balachandran L. Antibacterial agents from actinomycetes - a review. Front Biosci (Elite Ed). 2012 Jan 1;4:240-53. PMID: 22201868.Airoldi C, Colombo L, Manzoni C, et al. Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interaction. Org Biomol Chem. 2011 Jan 21;9(2):463-72. PMID: 21063627.Griffin MO, Fricovsky E, Ceballos G, et al. Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. PMID: 20592239.Hertweck M, Hiller R, Mueller MW. Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro. Eur J Biochem. 2002 Jan;269(1):175-83. PMID: 11784311.


メーカー 品番 包装
LKT T1679 100 G
希望販売価格 ¥25,000


当社在庫 なし
納期目安 1週間程度
保存温度 4℃




メーカー名 LKT Laboratories, Inc.
略号 LKT