別品名 |
3,4',5-Stilbenetrio, 3,4',5-Trihydroxystilbene, 1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)-
|
別包装 |
あり
|
純度 |
>=98%
|
分子量 |
228.24
|
CAS RN® |
501-36-0
|
化合物の概要 |
Phenolic phytoalexin found in soy, grapes, and peanuts. SIRT1 activator, MAO inhibitor.
|
構造 |
C14H12O3
|
溶媒 |
Soluble in DMSO and ethanol.
|
使用目的 |
Resveratrol and its metabolites are phenolic phytoalexins found in several plants such as soybeans, peanuts, blueberries, mulberries, and grapes. Resveratrol is most well known for its antioxidative effects and activation of SIRT1, both contributing to its cardioprotective, anticancer chemotherapeutic, chemopreventive, anti-aging, anti-inflammatory, and antiviral activities; it also acts as a phytoestrogen. Resveratrol reversibly inhibits MAO as well as synaptosomal 5-HT and NE uptake, indicating potential antidepressant activity. This compound also shows benefit in in vitro and in vivo models of Alzheimer’s disease, degrading amyloid-β (Aβ) plaques, increasing brain cysteine levels, and decreasing brain glutathione levels; these effects may be dependent on resveratrol’s activation of AMPK and/or proteasomes.
|
その他 |
[融点]254℃ [外観]White Powder
|
参考文献 |
Mohar DS, Malik S. The Sirtuin System: The Holy Grail of Resveratrol? J Clin Exp Cardiolog. 2012 Nov;3(11). 216. PMID: 23560248.Vingtdeux V, Giliberto L, Zhao H, et al. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem. 2010 Mar 19;285(12):9100-13. PMID: 20080969.Karuppagounder SS, Pinto JT, Xu H, et al. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochem Int. 2009 Feb;54(2):111-8. PMID: 19041676.Athar M, Back JH, Tang X, et al. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol. 2007 Nov 1;224(3):274-83. PMID: 17306316.Yanez M, Fraiz N, Cano E, et al. Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activity. Biochem Biophys Res Commun. 2006 Jun 2;344(2):688-95. PMID: 16631124.Marambaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J Biol Chem. 2005 Nov 11;280(45):37377-82. PMID: 16162502.Narayanan N, Nargi D, Randolph C, et al. Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. Int J Cancer. 2009 Feb 6;125(1):1-8. PMID: 19326431.Huang A, Yang YM, Yan C, et al. Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice. Diabetes. 2012 Dec;61(12):3181-3188. PMID: 22933112.Back JH, Rezvani HR, Zhu Y, et al. Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent inhibition of sirtuin 1. J Biol Chem. 2011 May 27;286(21):19100-19108. PMID: 21471201.
|
※サムネイル画像をクリックすると拡大画像が表示されます。
|
|
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
-20℃
|
|