別品名 |
Stylomycin aminonucleoside
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別包装 |
あり
|
純度 |
>=98%
|
分子量 |
294.31
|
CAS RN® |
58-60-6
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化合物の概要 |
Purine nucleoside analog; DNA chain terminator, DPP2 and metalloproteinase inhibitor.
|
構造 |
C12H18N6O3
|
溶媒 |
DMSO: 50mg/mlWater: 10mg/ml
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使用目的 |
Puromycin is an aminonucleoside antibiotic compound originally produced by Streptomyces alboniger. Puromycin displays antibacterial activity through inhibition of ribosomal protein translation; it resembles the 3’ end of tRNA and is incorporated into growing protein chains through the ribosomal A site, inducing premature chain termination. Puromycin also induces DNA damage mediated by ROS and oxidative stress in animal models. In vitro, puromycin inhibits insulin-stimulated glycolysis by inhibiting insulin activation of phosphofructokinase 2. Puromycin also inhibits dipeptidyl peptidase II (DPP2; serine peptidase) and metallopeptidase. Additionally, this compound induces ERK activation-dependent apoptosis and mTOR-dependent autophagy in podocytes, leading to proteinuria and glomerular damage.
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その他 |
[融点]215-216 ℃
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参考文献 |
Kang YL, Saleem MA, Chan KW, et al. The cytoprotective role of autophagy in puromycin aminonucleoside treated human podocytes. Biochem Biophys Res Commun. 2014 Jan 10;443(2):628-34. PMID: 24333414.Liu S, Ding J, Fan Q, et al. The activation of extracellular signal-regulated kinase is responsible for podocyte injury. Mol Biol Rep. 2010 Jun;37(5):2477-84. PMID: 19728154.Marshall CB, Pippin JW, Krofft RD, et al. Puromycin aminonucleoside induces oxidant-dependent DNA damage in podocytes in vitro and in vivo. Kidney Int. 2006 Dec;70(11):1962-73. PMID: 17035936.Probst I, Quentmeier A, Schweickhardt C, et al. Stimulation by insulin of glycolysis in cultured hepatocytes is attenuated by extracellular ATP and puromycin through purine-dependent inhibition of phosphofructokinase 2 activation. Eur J Biochem. 1989 Jun 15;182(2):387-93. PMID: 2525468.
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メーカー |
品番 |
包装 |
LKT
|
P8167
|
5 MG
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※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
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保存温度 |
4℃
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