別品名 |
Belcomycin, Colomycin syrup, Polymyxin E Complex
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別包装 |
あり
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純度 |
Biological Potency: >=19366 IU/mg
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分子量 |
1267.55
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CAS RN® |
1264-72-8
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化合物の概要 |
Polymixin, antimicrobial peptide, induces formation of pores in membrane; NADH quinone reductase inhibitor.
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構造 |
C45H85N13O10 H2O4S
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溶媒 |
Soluble in water (50 mg/mL).
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使用目的 |
Colistin is an antimicrobial peptide (AMP); it is a polymixin-family antibiotic initially produced by species of Bacillus. Colistin displays antibacterial efficacy against gram negative bacteria, interacting with the bacterial outer membrane, inducing the formation of pores. This peptide also inhibits NADH quinone oxidoreductase. Colistin is no longer commonly used due to associated neurotoxicity and nephrotoxicity.
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参考文献 |
Deris ZZ, Akter J, Sivanesan S, et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo). 2014 Feb;67(2):147-51. PMID: 24169795.Dai C, Zhang D, Gao R, et al. In vitro toxicity of colistin on primary chick cortex neurons and its potential mechanism. Environ Toxicol Pharmacol. 2013 Sep;36(2):659-66. PMID: 23892071.Manning AJ, Kuehn MJ. Contribution of bacterial outer membrane vesicles to innate bacterial defense. BMC Microbiol. 2011 Dec 1;11:258. PMID: 22133164.
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メーカー |
品番 |
包装 |
LKT
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C5647
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25 G
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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