AdipoRon, trial size  

分子量 428.52
CAS RN® 924416-43-3
構造 C27H28N2O3
使用目的 AdipoRon is a novel AdipoR agonist, binding to both AdipoR1 (Kd=1.8 μM) and AdipoR2 (Kd=3.1 μM).IC50 & Target: Kd: 1.8 μM (AdipoR1), 3.1 μM (AdipoR2)In Vitro: AdipoRon (50 μM) attenuates the expression of TNF-α and TGF-β1, apparently in a dose-dependent manner in the L02 cells. AdipoRon exhibits significant and dosage-dependent growth suppression on macrophages[1]. AdipoRon treatment significantly improves cardiac functional recovery after reperfusion, and inhibits post-MI apoptosis[2]. AdipoRon exerts vasodilation by mechanisms distinct to adiponectin. AdipoRon induces vasorelaxation without a marked decrease in VSMC [Ca2+]i[3].In Vivo: AdipoRon (0.02, 0.1, and 0.5 mg/kg, i.g.) alleviates D-GalN induced hepatotoxicity in mice. AdipoRon dose-dependently prevents hepatic architecture distortion against D-GalN challenge. The hepatoprotective potential of AdipoRon is particularly evident in higher dosages (0.1 and 0.5 mg/kg)[1]. Enhanced cardiomyocyte apoptosis in APN-deficient mice is rescued by AdipoRon (50 mg/kg, p.o.) administration. Antiapoptotic effect of AdipoRon is attenuated but not lost in AMPK-DN mice[2].
[注意事項] ※有償サンプルです※有償サンプルについては、1研究室あたり1年間3種各1本までです。


メーカー 品番 包装
MCH HY-15848 0.5 MG
希望販売価格 ¥5,000


当社在庫 なし
納期目安 約10日
保存温度 -20℃




メーカー名 MedChemexpress Co., limited
略号 MCH