PD153035, trial size  

別品名 ZM 252868;Tyrphostin AG 1517;AG 1517;SU 5271
分子量 360.2053
CAS RN® 153436-54-5
構造 C16H14BrN3O2
使用目的 PD153035(ZM 252868; AG 1517) is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect against PGDFR, FGFR, CSF-1, InsR and Src.IC50 value: 5.2/29 pM(Ki/IC50) [1]Target: EGFRin vitro: PD 153035 shows a potent and selective inhibitory effect on tyrosine phosphorylation induced with EGF with IC50 of 15 nM and 14 nM in Swiss 3T3 fibroblast and A-431 human epidermoid carcinoma cells, respectively [1]. PD153035 shows growth inhibitory effects in cultures of EGF receptor-overexpressing human cancer cell lines including A431, Difi, DU145, MDA-MB-468 and ME180 cells with IC50 of 0.22 μM, 0.3μM, 0.4 μM, 0.68 μM and 0.95 μM, respectively [2]. in vivo: In A431 human epidermoid tumors grown as xenografts in immunodeficient nude mice, PD153035 at 80 mg/kg inhibit EGF receptor tyrosine kinase activity [3]. PD153035 improves glucose tolerance, insulin sensitivity, and signaling and reduces subclinical inflammation in HFD-fed mice [4].
参考文献 Elife. 2015 Feb 10;4:e05178.
[注意事項] ※有償サンプルです※有償サンプルについては、1研究室あたり1年間3種各1本までです。


メーカー 品番 包装
MCH HY-14346 0.5 MG
希望販売価格 ¥5,000


当社在庫 なし
納期目安 約10日
保存温度 -20℃




メーカー名 MedChemexpress Co., limited
略号 MCH