別品名 |
3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole, [5-(1-Benzyl-1H-indazol-3-yl)-2-furyl]methanol
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別包装 |
あり
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純度 |
>=98%
|
分子量 |
304.35
|
CAS RN® |
170632-47-0
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化合物の概要 |
Guanylyl cyclase activator and HIF-1α inhibitor.
|
溶媒 |
Soluble in DMSO, methanol or dichloromethane.
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参考文献 |
Brownfoot FC, Tong S, Hannan NJ, et al. YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia. Mol Cell Endocrinol. 2015 Sep 15;413:202-8. PMID: 26159901.Xiao J, Jin C, Liu Z, et al. The design, synthesis, and biological evaluation of novel YC-1 derivatives as potent anti-hepatic fibrosis agents. Org Biomol Chem. 2015 Jul 14;13(26):7257-64. PMID: 26055070.Kambayashi S, Igase M, Kobayashi K, et al. Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphoma. J Vet Med Sci. 2015 Jun 6. [Epub ahead of print]. PMID: 26050843.Tsou CY, Chen CY, Zhao JF, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf). 2014 Apr;210(4):799-810. PMID: 24299003.Purohit R, Fritz BG, The J, et al. YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry. 2014 Jan 14;53(1):101-14. PMID: 24328155.Tsai YC, Lee YM, Lam KK, et al. The role of heat shock protein 70 in the protective effect of YC-1 on β-amyloid-induced toxicity in differentiated PC12 cells. PLoS One. 2013 Jul 26;8(7):e69320. PMID: 23922702.
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|
メーカー |
品番 |
包装 |
LKT
|
Y0800
|
25 MG
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
-20℃
|
|