|
※サムネイル画像をクリックすると拡大画像が表示されます。
|
|
|
| 概要 |
Echelon's LPLA2 Inhibitor Screen is a high throughput assay designed to screen drugs abilitiy to inhibit LPLA2 activity in vitro a potential predictor of drug-induced phospholipidosis.Sample Volume: 1 I？LSample Number: 128 Samples (in triplicates)/384-well plateEchelona？？s LPLA2 Inhibitor Screen (K-7000I) is designed to assay a drug's ability to inhibit LPLA2 activity in vitro and thus potentially predict DIPL. The assay uses a quenched substrate which fluoresces when hydrolyzed by LPLA2. This direct biochemical approach provides a quantitative measurement in a robust and simple-to-use in vitro plate-based assay providing greatly increased throughput when compared to traditional microscopy methods of tissue cultured cells. The assay has been validated with a group of known PL-inducing and non-PL inducing drugs. The known PL-inducing cationic amphiphilic drug amiodarone is included in the assay as a control.Product BackgroundHuman lysosomal phospholipase A2 (LPLA2 also known as Lp-PLA2 or PLA2G15) is responsible for normal lipid metabolism and it is unique from other known PLA2s in that LPLA2 is only active in an acidic environment (~pH 4.5). Phospholipidosis (PL) is a condition resulting from the excessive accumulation of intracellular phospholipids causing tissue inflammation and organ damage. PL can manifest in patients taking certain cationic amphiphilic drugs (CADs) such as fluoxetine (Prozaca？¢ Sarafem) and Amiodarone. The FDA has determined that drug-induced phospholipidosis (DIPL) is a serious drug safety issue and evidence is accumulating that DIPL is the result of certain CADs directly inhibiting LPLA2.
|
|
| メーカー |
品番 |
包装 |
|
ECL
|
K-7000I
|
1 EACH
[1kit]
|
※表示価格について
| 当社在庫 |
なし
|
| 納期目安 |
1週間程度
|
| 法規制 |
安
|
| 保存温度 |
-２０℃
|
|
※当社では商品情報の適切な管理に努めておりますが、表示される法規制情報は最新でない可能性があります。
また法規制情報の表示が無いものは、必ずしも法規制に非該当であることを示すものではありません。
商品のお届け前に最新の製品法規制情報をお求めの際はこちらへお問い合わせください。
|
※当社取り扱いの試薬・機器製品および受託サービス・創薬支援サービス（納品物、解析データ等）は、研究用としてのみ販売しております。
人や動物の医療用・臨床診断用・食品用としては、使用しないように、十分ご注意ください。
法規制欄に体外診断用医薬品と記載のものは除きます。
|
|
※リンク先での文献等のダウンロードに際しましては、掲載元の規約遵守をお願いします。
|
