| 純度 |
>99% by TLC
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| 分子量 |
453
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| CAS RN® |
99570-78-2
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| 化合物の概要 |
A Potent Inhibitor of Protein Kinase A, Protein Kinase C, and Protein Kinase G
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| 構造 |
C26H19N3O5
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| 溶媒 |
DMSO 又は DMFに溶解
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| 使用目的 |
K252に比べて活性の低い誘導体であり､K252aのﾈｶﾞﾃｨﾌﾞｺﾝﾄﾛｰﾙとして使われる｡
CAS#[99570-78-2]
Enzyme&tab;IC50(nM)
CaMK-II&tab;12
Myosine Light Chane Kinase&tab;147
PKA&tab;90
PKC&tab;20
PKG&tab;100
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| 参考文献 |
1. Nagashima, K. et al. (1991) Febs Lett. 293, 119. 2. Knusel, B. et al. (1992) J. Neurochem. 59, 715.
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※サムネイル画像をクリックすると拡大画像が表示されます。
ManufacturerBioassayAlomone Labs K252b inhibits MARCKS phosphorylation via PKC in C6 glioma cells. - Cells were grown to 70% confluence, and then serum starved for 18 h. The cells were preincubated for 30 min with different concentrations of？K252b？(#K-170) and stimulated with 2 μM？PMA？(#P-800) for 30 min. Cell proteins were resolved by SDS-PAGE and probed with anti-phospho (ser)- MARCKS (myristoylated alanine-rich protein kinase C substrate).
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ManufacturerBioassayAlomone Labs K252b inhibits MARCKS phosphorylation via PKC in C6 glioma cells. - Cells were grown to 70% confluence, and then serum starved for 18 h. The cells were preincubated for 30 min with different concentrations of？K252b？(#K-170) and stimulated with 2 μM？PMA？(#P-800) for 30 min. Cell proteins were resolved by SDS-PAGE and probed with anti-phospho (ser)- MARCKS (myristoylated alanine-rich protein kinase C substrate).
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| メーカー |
品番 |
包装 |
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ALO
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K-170
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50 UG
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※表示価格について
| 当社在庫 |
なし
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| 納期目安 |
約10日
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| 保存温度 |
-２０℃
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