別品名 |
MG-132
|
別包装 |
あり
|
純度 |
>=98%
|
分子量 |
475.62
|
CAS RN® |
133407-82-6
|
化合物の概要 |
Proteasome inhibitor.
|
構造 |
C26H41N3O5
|
溶媒 |
DMSO90 mg/mL (189.22 mM)Ethanol25 mg/mL (52.56 mM)WaterInsoluble
|
使用目的 |
MG-132 is a proteasome inhibitor that exhibits anti-fibrotic, anti-inflammatory, and anti-osteoarthritic activities. In renal interstitial fibroblasts, MG-132 inhibits proliferation and induces apoptosis by activating p53, p21, caspase 3, and Bax. MG-132 also inhibits skeletal muscle atrophy in animal models of chronic obstructive pulmonary disorder (COPD) by preventing degradation of IκB and activation of NF-κB. In other animal models, this compound delays progression of osteoarthritis by inhibiting inflammation in cartilage and synovial tissue.
|
参考文献 |
Zhu B, Jin Y, Han L, et al. Proteasome inhibitor inhibits proliferation and induces apoptosis in renal interstitial fibroblasts. Pharmacol Rep. 2013;65(5):1357-65. PMID: 24399732.Ma BM, Liu ZH, Liang ZK, et al. The proteasome inhibitor MG132 attenuates skeletal muscle atrophy in a rat model of chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi. 2013 Jun;36(6):441-6. PMID: 24103208.Quan R, Huang Z, Yue Z, et al. Effects of a proteasome inhibitor on the NF-κB signalling pathway in experimental osteoarthritis. Scand J Rheumatol. 2013;42(5):400-7. PMID: 23826657.
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|
メーカー |
品番 |
包装 |
LKT
|
M2400
|
25 MG
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
-20℃
|
|