別品名 NVP-BEZ235, Dactolisib
別包装 あり
純度 >=98%
分子量 469.54
CAS RN® 915019-65-7
化合物の概要 PI3K and mTOR inhibitor.
構造 C30H23N5O
溶媒 DMF18 mg/mL warmed (38.33 mM)DMSO0.01 mg/mL (0.02 mM)WaterInsoluble
使用目的 BEZ235 inhibits PI3K and mTORC1/2, exhibiting anticancer chemotherapeutic activity. In nasopharyngeal cancer cells, BEZ235 induces G1 phase cell cycle arrest and apoptosis; in similar animal models of nasopharyngeal or cholangiocarcinoma, this compound inhibits tumor growth. BEZ235 also induces apoptosis in hepatocellular carcinoma cells, also potentially inducing autophagy.
参考文献 Ma BB, Lui VW, Hui CW, et al. Preclinical evaluation of the mTOR-PI3K inhibitor BEZ235 in nasopharyngeal cancer models. Cancer Lett. 2014 Feb 1;343(1):24-32. PMID: 24041865.Yothaisong S, Dokduang H, Techasen A, et al. Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy. Tumour Biol. 2013 Dec;34(6):3637-48. PMID: 23832540.Chang Z, Shi G, Jin J, et al. Dual PI3K/mTOR inhibitor NVP-BEZ235-induced apoptosis of hepatocellular carcinoma cell lines is enhanced by inhibitors of autophagy. Int J Mol Med. 2013 Jun;31(6):1449-56. PMID: 23588698.
メーカー 品番 包装
LKT B1996 25 MG
希望販売価格 ¥18,000


当社在庫 なし
納期目安 1週間程度
保存温度 -20℃




メーカー名 LKT Laboratories, Inc.
略号 LKT